The osteosarcoma microenvironment: a complex but targetable ecosystem

I Corre, F Verrecchia, V Crenn, F Redini, V Trichet - Cells, 2020 - mdpi.com
Osteosarcomas are the most frequent primary bone sarcomas, affecting mainly children,
adolescents, and young adults, and with a second peak of incidence in elderly individuals …

Vasculogenic mimicry, a complex and devious process favoring tumorigenesis–interest in making it a therapeutic target

L Treps, S Faure, N Clere - Pharmacology & therapeutics, 2021 - Elsevier
Tumor cell vasculogenic mimicry (VM), also dubbed vascular mimicry, describes the
plasticity of aggressive cancer cells forming de novo vascular networks and is associated …

Targeting ROCK/LIMK/cofilin signaling pathway in cancer

MH Lee, JK Kundu, JI Chae, JH Shim - Archives of pharmacal research, 2019 - Springer
Rho-associated coiled-coil-containing protein kinase (ROCK)/Lin11, Isl-1 and Mec-3 kinase
(LIMK)/cofilin-signaling cascades are stimulated by receptor tyrosine kinases, G protein …

Overview of advances in vasculogenic mimicry–a potential target for tumor therapy

H Ge, H Luo - Cancer management and research, 2018 - Taylor & Francis
Vasculogenic mimicry (VM) describes the process utilized by highly aggressive cancer cells
to generate vascular-like structures without the presence of endothelial cells. VM has been …

LncRNA-SMILR modulates RhoA/ROCK signaling by targeting miR-141 to regulate vascular remodeling in pulmonary arterial hypertension

S Lei, F Peng, ML Li, WB Duan… - American Journal of …, 2020 - journals.physiology.org
Pulmonary arterial hypertension (PAH) is a fatal progressive disease characterized by an
increased blood pressure in the pulmonary arteries. RhoA/Rho-kinase (RhoA/ROCK) …

The role of sema4D in vasculogenic mimicry formation in non‐small cell lung cancer and the underlying mechanisms

Y Xia, XY Cai, JQ Fan, LL Zhang… - … journal of cancer, 2019 - Wiley Online Library
Vasculogenic mimicry (VM) is a special vascular pattern in malignant tumors, which is
composed of highly aggressive tumor cells. This tumor cell‐mediated blood supply pattern is …

Hyponatremia and cancer: from bedside to benchside

B Fibbi, G Marroncini, L Naldi, C Anceschi, A Errico… - Cancers, 2023 - mdpi.com
Simple Summary This review article is focused on hyponatremia in cancer patients.
Hyponatremia is the most common electrolyte disorder in these patients and there is …

Advanced glycation end products induce immature angiogenesis in in vivo and ex vivo mouse models

L Chen, Y Cui, B Li, J Weng, W Wang… - American Journal …, 2020 - journals.physiology.org
Proliferative diabetic retinopathy (PDR) is a progressive disease predominantly involving
pathological angiogenesis and is characterized by the development of immature, fragile …

LncRNA PAXIP1‐AS1 fosters the pathogenesis of pulmonary arterial hypertension via ETS1/WIPF1/RhoA axis

R Song, S Lei, S Yang, SJ Wu - Journal of Cellular and …, 2021 - Wiley Online Library
Pulmonary arterial hypertension (PAH) is a life‐threatening disease featured with elevated
pulmonary vascular resistance and progressive pulmonary vascular remodelling. It has …

Baicalein suppresses vasculogenic mimicry through inhibiting RhoA/ROCK expression in lung cancer A549 cell line

Z Zhang, L Nong, M Chen, X Gu, W Zhao… - Acta biochimica et …, 2020 - academic.oup.com
Vasculogenic mimicry (VM) refers to a new tubular network of the blood supply system with
abundant extracellular matrix. VM is similar to capillaries but does not involve endothelial …