Background Steroid‐sparing strategies have been attempted in recent decades to avoid
morbidity from long‐term steroid intake among kidney transplant recipients. Previous …

Despite their clinical efficacy, concerns about calcineurin inhibitor (CNI) toxicity make
alternative regimens that reduce CNI exposure attractive for renal transplant recipients. In …

Background Calcineurin inhibitors (CNI) can reduce acute transplant rejection and
immediate graft loss but are associated with significant adverse effects such as hypertension …

Mammalian target of rapamycin inhibitors (mTOR‐I) lacks nephrotoxicity, has antineoplastic
effects, and reduces viral infections in kidney transplant recipients. Earlier studies reported a …

Sirolimus (SRL) is a mammalian target of rapamycin inhibitor, which provides an
immunosuppressive effect by inhibiting cell cycle progression. The encouraging results of …

Sirolimus (SRL)-based immunosuppressive regimens have been used for preventing
rejection after kidney transplantation. This review analyzes their merits and demerits …

Background: Long-term efficacy and safety of de novo use of the mammalian target of
rapamycin inhibitors (mTORi) have been evaluated primarily using registry data. Methods …

Cardiovascular disease (CVD) as defined by the American Heart Association includes
ischaemic heart disease, stroke, heart failure and thromboembolism [1]. Solid organ …

TORREGROSA, José V. et al. Tratamiento eficaz de la arteriolopatía urémica calcificante
con bifosfonatos. Nefrología (Madr.)[online]. 2012, vol. 32, n. 3, pp. 329-334. ISSN 0211 …

Here, we review 15 years of clinical use of sirolimus in our transplant center, in context with
the developing immunosuppressive strategies use worldwide. The majority of studies were …