A novel wound healing material composed of chitosan (Ch) and hyaluronan (HA) boosted
with edaravone (Ed) as an anti-inflammatory drug was developed. The fabricated …

The FDA-approved drug edaravone has a neuroprotective effect on spinal cord injury (SCI)
and many other central nervous system diseases. However, its molecular mechanism …

Background Lovastatin, as a drug of statins subgroup, has been conceptualized to have anti-
inflammatory, antioxidant, and anti-apoptotic properties. Accordingly, the present study …

Background Spinal cord injury (SCI) is one of the most disabling neurological conditions,
afflicting thousands of human beings. Edaravone, a well-known reactive oxygen species …

Background An excessive inflammatory response accompanies the pathogenesis of spinal
cord injury (SCI) and has been found to be promoted by inflammasomes in a variety of …

Background The mitochondrial dysfunction and following oxidative stress, as well as the
spread of inflammation plays major roles in the failure to regenerate following severe spinal …

Aims The activation of NLRP3 inflammasome, which initiates an inflammatory cascade and
triggers inflammatory death, plays a crucial role in the pathogenesis of spinal cord injury …

Oxidative protein damage involving carbonylation of respiratory tract proteins typically
accompanies exposure to tobacco smoke. Such damage can arise via multiple mechanisms …

The disruption of the blood spinal cord barrier (BSCB) after spinal cord injury (SCI) can
trigger secondary tissue damage. Edaravone is likely to protect the BSCB as a free radical …

Aims Edaravone potentially alleviates cognitive deficits in a mouse model of Alzheimer's
disease (AD). However, the mechanism of edaravone in suppressing AD progression …