In multicellular systems, oriented cell divisions are essential for morphogenesis and
homeostasis as they determine the position of daughter cells within the tissue and also, in …

Highlights•The most common interaction is a short, negatively-charged peptide binding
across a groove formed by two to three TPRs.•Longer peptides bind in an extended …

Both cell–cell adhesion and oriented cell division play prominent roles in establishing tissue
architecture, but it is unclear how they might be coordinated. Here, we demonstrate that the …

In any mitotic cell, the orientation of the mitotic spindle determines the orientation of the
cleavage plane and therefore the position of the two daughter cells. When combined with …

The nuclear mitotic apparatus (NuMA) protein is well conserved in vertebrates, and
dynamically changes its subcellular localization from the interphase nucleus to the …

Correct positioning of the spindle governs placement of the cytokinesis furrow and thus
plays a crucial role in the partitioning of fate determinants and the disposition of daughter …

Asymmetric cell divisions allow stem cells to balance proliferation and differentiation. During
embryogenesis, murine epidermis expands rapidly from a single layer of unspecified basal …

Oriented cell divisions are critical for the formation and maintenance of structured epithelia.
Proper mitotic spindle orientation relies on polarised anchoring of force generators to the …

Polarized epithelia form by oriented cell divisions in which the mitotic spindle aligns parallel
to the epithelial plane. To orient the mitotic spindle, cortical cues trigger the recruitment of …

During development, the establishment of proper tissue architecture depends upon the
coordinated control of cell divisions not only in space and time, but also direction. Execution …