The stage at which ribosomes are recruited to messenger RNAs (mRNAs) is an elaborate
and highly regulated phase of protein synthesis. Upon completion of this step, a ribosome is …

RNA-binding proteins (RBPs) regulate essentially every event in the lifetime of an RNA
molecule, from its production to its destruction. Whereas much has been learned about RNA …

The past several years have seen dramatic leaps in our understanding of how gene
expression is rewired at the translation level during tumorigenesis to support the …

Translation of aberrant mRNAs can cause ribosomes to stall, leading to collisions with
trailing ribosomes. Collided ribosomes are specifically recognised by ZNF598 to initiate …

Translational control in eukaryotic cells is critical for gene regulation during nutrient
deprivation and stress, development and differentiation, nervous system function, aging, and …

MicroRNAs constitute a large family of small, approximately 21-nucleotide-long, non-coding
RNAs that have emerged as key post-transcriptional regulators of gene expression in …

The central role of translation in modulating gene activity has long been recognized, yet the
systematic exploration of quantitative changes in translation at a genome-wide scale in …

MicroRNAs (miRNAs) are∼ 21-nucleotide-long RNA molecules regulating gene expression
in multicellular eukaryotes. In metazoa, miRNAs act by imperfectly base-pairing with the 3 …

The RBR (RING-BetweenRING-RING) or TRIAD [two RING fingers and a DRIL (double
RING finger linked)] E3 ubiquitin ligases comprise a group of 12 complex multidomain …

MicroRNAs are sequence-specific regulators of post-transcriptional gene expression in
many eukaryotes. They are believed to control the expression of thousands of target …