Phase separation organizes the site of autophagosome formation

Y Fujioka, JM Alam, D Noshiro, K Mouri, T Ando… - Nature, 2020 - nature.com
Many biomolecules undergo liquid–liquid phase separation to form liquid-like condensates
that mediate diverse cellular functions,. Autophagy is able to degrade such condensates …

[HTML][HTML] Artificial protein cages–inspiration, construction, and observation

I Stupka, JG Heddle - Current Opinion in Structural Biology, 2020 - Elsevier
Highlights•Protein cages are nanoscale containers with a multitude of potential uses and are
widely found in nature.•The ability to produce artificial protein cages offers the prospect of …

[HTML][HTML] Natural and artificial protein cages: design, structure and therapeutic applications

JG Heddle, S Chakraborti, K Iwasaki - Current opinion in structural biology, 2017 - Elsevier
Highlights•Structural analysis of icosahedral and non-icosahedral viral capsids using
advanced cryo-electron microscopy techniques.•Advances in subtomogram averaging have …

An ultra-stable gold-coordinated protein cage displaying reversible assembly

AD Malay, N Miyazaki, A Biela, S Chakraborti… - Nature, 2019 - nature.com
Symmetrical protein cages have evolved to fulfil diverse roles in nature, including
compartmentalization and cargo delivery, and have inspired synthetic biologists to create …

Chemically induced protein cage assembly with programmable opening and cargo release

I Stupka, Y Azuma, AP Biela, M Imamura… - Science …, 2022 - science.org
Engineered protein cages are promising tools that can be customized for applications in
medicine and nanotechnology. A major challenge is developing a straightforward strategy …

Visualization of bacterial microcompartment facet assembly using high-speed atomic force microscopy

M Sutter, M Faulkner, C Aussignargues, BC Paasch… - Nano …, 2016 - ACS Publications
Bacterial microcompartments (BMCs) are proteinaceous organelles widespread among
bacterial phyla. They compartmentalize enzymes within a selectively permeable shell and …

Artificial protein cage delivers active protein cargos to the cell interior

A Naskalska, K Borzęcka-Solarz, J Rozycki… - …, 2021 - ACS Publications
Artificial protein cages have potential as programmable, protective carriers of fragile
macromolecules to cells. While natural cages and VLPs have been extensively exploited …

Artificial protein cage with unusual geometry and regularly embedded gold nanoparticles

K Majsterkiewicz, AP Biela, S Maity, M Sharma… - Nano Letters, 2022 - ACS Publications
Artificial protein cages have great potential in a number of areas including cargo capture
and delivery and as artificial vaccines. Here, we investigate an artificial protein cage whose …

Applications of high-speed atomic force microscopy to real-time visualization of dynamic biomolecular processes

T Uchihashi, S Scheuring - Biochimica et Biophysica Acta (BBA)-General …, 2018 - Elsevier
Background Many biological processes in a living cell are consequences of sequential and
hierarchical dynamic events of biological macromolecules such as molecular interactions …

Light‐Triggered Disassembly of Molecular Motor‐based Supramolecular Polymers Revealed by High‐Speed AFM

C van Ewijk, F Xu, S Maity, J Sheng… - Angewandte Chemie …, 2024 - Wiley Online Library
Photoresponsive supramolecular polymers have a major potential for applications in
responsive materials that are externally triggered by light with spatio‐temporal control of …