Microglia are the resident macrophages of the central nervous system (CNS) acting as the
first line of defense in the brain by phagocytosing harmful pathogens and cellular debris …

The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …

Recent studies have begun to reveal critical roles for the brain's professional phagocytes,
microglia, and their receptors in the control of neurotoxic amyloid beta (Aβ) and myelin …

Alzheimer's disease (AD) is a complex neurodegenerative disease, perturbing neuronal and
non-neuronal cell populations. In this study, using single-cell transcriptomics, we mapped all …

While many drugs are effective at reducing the relapse frequency of multiple sclerosis (MS),
there is an unmet need for treatments that slow neurodegeneration resulting from secondary …

In neurological diseases, the actions of microglia, the resident myeloid cells of the CNS
parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive …

For a long time, viruses have been shown to modify the clinical picture of several
autoimmune diseases, including type 1 diabetes (T1D), systemic lupus erythematosus …

Rapid advances in the isolation of multipotent progenitor cells, routinely called
mesenchymal stromal/stem cells (MSCs), from various human tissues and organs have …

The mammalian brain contains neurogenic niches that comprise neural stem cells and other
cell types. Neurogenic niches become less functional with age, but how they change during …

Induced tolerogenic dendritic cells are a powerful immunotherapy for autoimmune disease
that have shown promise in laboratory models of disease and early clinical trials. In contrast …