The kidneys play a key role in maintaining total body homeostasis. The complexity of this
task is reflected in the unique architecture of the organ. Ureteral obstruction greatly affects …

Simple Summary The tumor microenvironment plays an important role in determining the
biological behavior of several of the more aggressive malignancies. Among the various cell …

Abstract p53 is a major regulator of cell cycle arrest, apoptosis, and senescence. While
involvement of p53 in tumorigenesis is well established, recent studies implicate p53 in the …

Kidney fibrosis is associated with the progression of acute kidney injury to chronic kidney
disease. MG53, a cell membrane repair protein, has been shown to protect against injury to …

In obesity-associated non-alcoholic steatohepatitis (NASH), persistent hepatocellular
damage and inflammation are key drivers of fibrosis, which is the main determinant of NASH …

Wogonin, a vital bioactive compound extracted from the medicinal plant, Scutellaria
baicalensis, has been wildly used for its potential in mitigating the progression of chronic …

A heterogenous population of inflammatory elements, other immune and nonimmune cells
and cancer-associated fibroblasts (CAFs) are evident in solid malignancies where they …

The tumor suppressor p53, primarily functioning as a transcription factor, has exhibited
antiviral capabilities against various viruses in chickens, including infectious bursal disease …

Background Ureteropelvic junction obstruction (UPJO) is one of the most common causes of
hydronephrosis in children. This study explored the effects and the regulatory mechanisms …

Renal tubulointerstitial fibrosis (RTIF) is a common feature and inevitable consequence of all
progressive chronic kidney diseases, leading to end-stage renal failure regardless of the …