Molecular mechanics Poisson–Boltzmann surface area (MM/PBSA) and molecular
mechanics generalized Born surface area (MM/GBSA) are arguably very popular methods …

G protein–coupled receptors (GPCRs) constitute the largest family of membrane proteins in
the human genome and are important therapeutic targets. During the last decade, the …

Two-thirds of human hormones and one-third of clinical drugs activate~ 350 G-protein-
coupled receptors (GPCR) belonging to four classes: A, B1, C and F. Whereas a model of …

In protein microcrystallography, radiation damage often hampers complete and high-
resolution data collection from a single crystal, even under cryogenic conditions. One …

Abstract Narcolepsy type 1 (NT1) is a chronic neurological disorder that impairs the brain's
ability to control sleep-wake cycles. Current therapies are limited to the management of …

Owing to the development of brilliant microfocus beamlines, rapid-readout detectors and
sample changers, protein microcrystallography is rapidly becoming a popular technique for …

G protein-coupled receptors (GPCRs) have evolved to recognize incredibly diverse
extracellular ligands while sharing a common architecture and structurally conserved …

The melanocortin-4 receptor (MC4R) is involved in energy homeostasis and is an important
drug target for syndromic obesity. We report the structure of the antagonist SHU9119-bound …

Ghrelin is a gastric peptide hormone with important physiological functions. The unique
feature of ghrelin is its Serine 3 acyl-modification, which is essential for ghrelin's activity …

Identifying the genetic factors that underlie complex traits is central to understanding the
mechanistic underpinnings of evolution. Cave-dwelling Astyanax mexicanus populations …