Recent progress in understanding the action of natural compounds at novel therapeutic drug targets for the treatment of liver cancer

Y Zheng, W Zhang, L Xu, H Zhou, M Yuan… - Frontiers in …, 2022 - frontiersin.org
Liver cancer is the third most common cause of cancer-related death following lung and
stomach cancers. As a highly lethal disease, liver cancer is diagnosed frequently in less …

Recent advances regarding the molecular mechanisms of triterpenic acids: A review (part I)

M Mioc, A Milan, D Malița, A Mioc, A Prodea… - International Journal of …, 2022 - mdpi.com
Triterpenic acids are phytocompounds with a widespread range of biological activities that
have been the subject of numerous in vitro and in vivo studies. However, their underlying …

[HTML][HTML] Antrodia cinnamomea exerts an anti-hepatoma effect by targeting PI3K/AKT-mediated cell cycle progression in vitro and in vivo

Y Zhang, P Lv, J Ma, N Chen, H Guo, Y Chen… - … Pharmaceutica Sinica B, 2022 - Elsevier
Antrodia cinnamomea is extensively used as a traditional medicine to prevention and
treatment of liver cancer. However, its comprehensive chemical fingerprint is uncertain, and …

Therapeutic potential of oleanolic acid in liver diseases

Y Wang, K Liu - Naunyn-Schmiedeberg's Archives of Pharmacology, 2024 - Springer
Liver-associated diseases affect millions of individuals worldwide. In developed countries,
the incidence of viral hepatitis is reducing due to advancements in disease prevention …

Targeting Akt/NF-κB/p53 Pathway and Apoptosis Inducing Potential of 1,2-Benzenedicarboxylic Acid, Bis (2-Methyl Propyl) Ester Isolated from Onosma bracteata Wall …

A Kumar, S Kaur, S Dhiman, PP Singh, G Bhatia… - Molecules, 2022 - mdpi.com
Onosma bracteata Wall. is an important medicinal and immunity-enhancing herbs. This plant
is commonly used in the preparation of traditional Ayurvedic drugs to treat numerous …

Pentacyclic Triterpenes from Olive Leaves Formulated in Microemulsion: Characterization and Role in De Novo Lipogenesis in HepG2 Cells

M Vasarri, D Degl'Innocenti, L Albonetti… - International Journal of …, 2023 - mdpi.com
Olea europaea L. leaves contain a wide variety of pentacyclic triterpenes (TTPs). TTPs
exhibit many pharmacological activities, including antihyperlipidemic effects. Metabolic …

[HTML][HTML] Principal Bioactive Properties of Oleanolic Acid, Its Derivatives, and Analogues

F Jannus, J Sainz, FJ Reyes-Zurita - Molecules, 2024 - mdpi.com
Natural products have always played an important role in pharmacotherapy, helping to
control pathophysiological processes associated with human disease. Thus, natural …

Evaluation of Anticancer and Anti-Inflammatory Activities of Some Synthetic Rearranged Abietanes

M Ait El Had, H Zentar, B Ruiz-Muñoz, J Sainz… - International Journal of …, 2023 - mdpi.com
Synthesis of the rearranged abietane diterpenes pygmaeocins C and D, viridoquinone,
saprorthoquinone, and 1-deoxyviroxocine has been successfully achieved. The anticancer …

Semisynthesis and Evaluation of Anti-Inflammatory Activity of the Cassane-Type Diterpenoid Taepeenin F and of Some Synthetic Intermediates

H Zentar, F Jannus, P Gutierrez… - Journal of Natural …, 2022 - ACS Publications
A new strategy for the semisynthesis of the aromatic cassane-type diterpene taepeenin F (6)
is reported. The introduction of the methyl group at C-14, characteristic of the target …

Efficient in vitro and in vivo anti-inflammatory activity of a diamine-PEGylated oleanolic acid derivative

F Jannus, M Medina-O'Donnell, VE Neubrand… - International Journal of …, 2021 - mdpi.com
Recent evidence has shown that inflammation can contribute to all tumorigenic states. We
have investigated the anti-inflammatory effects of a diamine-PEGylated derivative of …