Antiseizure drugs (ASDs) prevent the occurrence of seizures; there is no evidence that they
have disease-modifying properties. In the more than 160 years that orally administered …

The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …

Symptomatic treatment of neuropathic pain in small fibre neuropathy is often disappointing.
The finding of voltage-gated sodium channel mutations in small fibre neuropathy (with …

Background Small fiber neuropathy (SFN) is a severe and disabling chronic pain syndrome
with no causal and limited symptomatic treatment options. Mechanistically based individual …

Objective Voltage‐gated sodium (Na+) channels underlie action potential generation and
propagation and hence are central to the regulation of excitability in the nervous system …

Purpose Diabetic peripheral neuropathy (DPN) is the most common complication of
diabetes. Small and large peripheral nerve fibers can be involved in DPN. Large nerve fiber …

Epilepsy is one of the most common brain disorders, affecting more than 50 million people
worldwide. Although its treatment is currently symptomatic, the last generation of anti-seizure …

Small fibre neuropathy is a common pain disorder, which in many cases fails to respond to
treatment with existing medications. Gain-of-function mutations of voltage-gated sodium …

Neuropathic pain (NeuP) is defined as pain arising from a lesion or disease of the
somatosensory nervous system. 38, 86 Neuropathic pain is common, affecting …

Persistent sodium current (INaP) is an important activity-dependent regulator of neuronal
excitability. It is involved in a variety of physiological and pathological processes, including …