Signal peptides (SP) are short peptides located in the N-terminal of proteins, carrying
information for protein secretion. They are ubiquitous to all prokaryotes and eukaryotes. SPs …

The HEK293 cell line has earned its place as a producer of biotherapeutics. In addition to its
ease of growth in serum-free suspension culture and its amenability to transfection, this cell …

The authors have retracted this article [1]. After the publication of this article, it came to the
authors attention that in order to support the conclusions of the study, the authors should …

Mammalian cells, eg, CHO, BHK, HEK293, HT-1080, and NS0 cells, represent important
manufacturing platforms in bioengineering. They are widely used for the production of …

A molecular hallmark in Parkinson's disease (PD) pathogenesis are α-synuclein aggregates.
Cerebral dopamine neurotrophic factor (CDNF) is an atypical growth factor that is mostly …

Expression of recombinant genes in HEK293 cells is frequently utilized for production of
recombinant proteins and viral vectors. These systems frequently employ the …

Cell line development (CLD) by random integration (RI) can be labor intensive, inconsistent,
and unpredictable due to uncontrolled gene integration after transfection. Unlike RI, targeted …

Detection of specific proteins using nanopores is currently challenging. To address this
challenge, we developed a collection of over twenty nanopore-addressable protein tags …

In the present study, six commonly used promoters, including cytomegalovirus major
immediate-early (CMV), the CMV enhancer fused to the chicken beta-actin promoter (CAG) …

Arrhythmogenic cardiomyopathy (ACM) is a hereditary myocardial disease characterized by
the replacement of the ventricular myocardium with fibrous fatty deposits. ACM is usually …