Around half of all protein structures solved nowadays using solution-state nuclear magnetic
resonance (NMR) spectroscopy have been because of automated data analysis. The …

Carbohydrate recognition is essential for growth, cell adhesion and signalling in all living
organisms. A highly conserved carbohydrate binding module, LysM, is found in proteins …

Coupling of fast protein dynamics to enzyme chemistry is controversial and has ignited
considerable debate, especially over the past 15 years in relation to enzyme-catalyzed H …

Contents 1. Introduction............................................................................. 33 1.1. Automated
structure determination methods in the postgenomics area.............................. 34 2. Automated …

Phosphoryl transfer reactions are ubiquitous in biology and metal fluoride complexes have
played a central role in structural approaches to understanding how they are catalyzed. In …

Ribosomes bind to many metabolic enzymes and change their activity. A general
mechanism for ribosome-mediated amplification of metabolic enzyme activity, RAMBO, was …

Glycolysis plays a fundamental role in energy production and metabolic homeostasis. The
intracellular [adenosine triphosphate]/[adenosine diphosphate]([ATP]/[ADP]) ratio controls …

Identifying how enzymes stabilize high-energy species along the reaction pathway is central
to explaining their enormous rate acceleration. β-Phosphoglucomutase catalyses the …

Approximately 75% of eukaryotic proteins contain more than one so-called independently
folding domain. However, there have been relatively few systematic studies to investigate …

Abstract Mutations in polycystin-1 (PC1) give rise to autosomal dominant polycystic kidney
disease, an important and common cause of kidney failure. Despite its medical importance …