The pathogenetic mechanisms underlying the onset and the post-transplant recurrence of
primary focal segmental glomerulosclerosis (FSGS) are complex and remain yet to be fully …

Abstract Antibody-mediated rejection (AMR), including chronic AMR (cAMR), causes~ 50%
of kidney allograft losses each year. Despite attempts to develop well-tolerated and effective …

Neutrophils are the most abundant of the circulating immune cells and are the first to be
recruited to sites of inflammation. Neutrophils are a heterogeneous group of immune cells …

Chondrocyte ferroptosis induces the occurrence of osteoarthritis (OA). As a key gene of OA,
C5a receptor 1 (C5AR1) is related to ferroptosis. Here, we investigated whether C5AR1 …

Transplantation is the ideal therapy for end-stage organ failure, but outcomes for all
transplant organs are suboptimal, underscoring the need to develop novel approaches to …

I have read with keen interest the article by Cumpelik et al.(1), which presents a pioneering
investigation into a novel T cell–independent pathway of B1 cell activation through …

Even within a single protein, antibody binding can have beneficial, neutral, or harmful effects
during the response to infection. Resolving a polyclonal antibody repertoire across a …

Marginal zone (MZ) B cells bridge innate and adaptive immunity by sensing bloodborne
antigens and producing rapid antibody and cytokine responses. CD55 is a membrane …