In vivo cell fate conversions have emerged as potential regeneration-based therapeutics for
injury and disease. Recent studies reported that ectopic expression or knockdown of certain …

Nucleocytoplasmic transport (NCT) across the nuclear envelope is precisely regulated in
eukaryotic cells, and it plays critical roles in maintenance of cellular homeostasis …

Lamin B1 is an essential protein of the nuclear lamina that plays a crucial role in nuclear
function and organization. It has been demonstrated that lamin B1 is essential for …

DYT1 dystonia is a debilitating neurological movement disorder arising from mutation in the
AAA+ ATPase TorsinA. The hallmark of Torsin dysfunction is nuclear envelope blebbing …

The nuclear pore complex (NPC) is among the most elaborate protein complexes in
eukaryotes. While ribosomes and proteasomes are known to require dedicated assembly …

Generation of neurons from human induced pluripotent stem cells (hiPSCs) overcomes the
limited access to human brain samples and greatly facilitates the progress of research in …

The nuclear pore complex (NPC) has long been assumed to be the sole route across the
nuclear envelope, and under normal homeostatic conditions it is indeed the main …

DYT-TOR1A dystonia is a neurological disorder characterized by involuntary muscle
contractions and abnormal movements. It is a severe genetic form of dystonia caused by …

Generation of motor neurons (MNs) from human-induced pluripotent stem cells (hiPSCs)
overcomes the limited access to human brain tissues and provides an unprecedent …

The discovery of biological pathways shared between different monogenic dystonias is an
important conceptual advance in the understanding of the underlying mechanisms, with a …