Subcellular compartmentalization in the biosynthesis and engineering of plant natural produces

L Yao, X Wu, X Jiang, M Shan, Z Zhang, Y Li… - Biotechnology …, 2023 - Elsevier
Plant natural products (PNPs) are specialized metabolites with diverse bioactivities. They
are extensively used in the pharmaceutical, cosmeceutical and food industries. PNPs are …

Emerging mechanistic insights into the regulation of specialized metabolism in plants

LV Méteignier, HW Nützmann, N Papon, A Osbourn… - Nature plants, 2023 - nature.com
Plants biosynthesize a broad range of natural products through specialized and species-
specific metabolic pathways that are fuelled by core metabolism, together forming a …

NextDenovo: an efficient error correction and accurate assembly tool for noisy long reads

J Hu, Z Wang, Z Sun, B Hu, AO Ayoola, F Liang, J Li… - Genome Biology, 2024 - Springer
Long-read sequencing data, particularly those derived from the Oxford Nanopore
sequencing platform, tend to exhibit high error rates. Here, we present NextDenovo, an …

Characterization of the horse chestnut genome reveals the evolution of aescin and aesculin biosynthesis

W Sun, Q Yin, H Wan, R Gao, C Xiong, C Xie… - Nature …, 2023 - nature.com
Horse chestnut (Aesculus chinensis) is an important medicinal tree that contains various
bioactive compounds, such as aescin, barrigenol-type triterpenoid saponins (BAT), and …

Revealing evolution of tropane alkaloid biosynthesis by analyzing two genomes in the Solanaceae family

F Zhang, F Qiu, J Zeng, Z Xu, Y Tang, T Zhao… - Nature …, 2023 - nature.com
Tropane alkaloids (TAs) are widely distributed in the Solanaceae, while some important
medicinal tropane alkaloids (mTAs), such as hyoscyamine and scopolamine, are restricted …

Plant biosynthetic gene clusters in the context of metabolic evolution

SJ Smit, BR Lichman - Natural Product Reports, 2022 - pubs.rsc.org
Covering: up to 2022 Plants produce a wide range of structurally and biosynthetically
diverse natural products to interact with their environment. These specialised metabolites …

Functional divergence of CYP76AKs shapes the chemodiversity of abietane-type diterpenoids in genus Salvia

J Hu, S Qiu, F Wang, Q Li, CL Xiang, P Di, Z Wu… - Nature …, 2023 - nature.com
Abstract The genus Salvia L.(Lamiaceae) comprises myriad distinct medicinal herbs, with
terpenoids as one of their major active chemical groups. Abietane-type diterpenoids (ATDs) …

Molecular insights into self-incompatibility systems: From evolution to breeding

D Zhang, YY Li, X Zhao, C Zhang, DK Liu, S Lan… - Plant …, 2024 - cell.com
Plants have evolved diverse self-incompatibility (SI) systems for outcrossing. Since Darwin's
time, considerable progress has been made toward elucidating this unrivaled reproductive …

Uncovering a miltiradiene biosynthetic gene cluster in the Lamiaceae reveals a dynamic evolutionary trajectory

AE Bryson, ER Lanier, KH Lau, JP Hamilton… - Nature …, 2023 - nature.com
The spatial organization of genes within plant genomes can drive evolution of specialized
metabolic pathways. Terpenoids are important specialized metabolites in plants with diverse …

Natural products of medicinal plants: biosynthesis and bioengineering in post-genomic era

L Guo, H Yao, W Chen, X Wang, P Ye, Z Xu… - Horticulture …, 2022 - academic.oup.com
Globally, medicinal plant natural products (PNPs) are a major source of substances used in
traditional and modern medicine. As we human race face the tremendous public health …