Damage-associated molecular patterns (DAMPs) are endogenous molecules released by
cells in response to injury or stress, recognized by host pattern recognition receptors that …

Senescent neural progenitor cells have been identified in brain lesions of people with
progressive multiple sclerosis (PMS). However, their role in disease pathobiology and …

With increasing age, the optimal functioning of the choroid is essential for efficient removal of
waste products formed from photoreceptor renewal. A decline in regulatory elements of the …

Purpose: Dysregulated cholesterol metabolism is critical in the pathogenesis of AMD.
Cellular senescence contributes to the development of numerous age-associated diseases …

CD38 is a transmembrane protein expressed in immune and non-immune cells involved in
nicotinamide adenine dinucleotide (NAD+) consumption, cyclic Adenosine Diphosphate …

Multiple sclerosis (MS), the most prevalent inflammatory autoimmune disorder affecting the
central nervous system (CNS), results in the deterioration of myelin sheaths and neuronal …

Nerve regeneration within the central nervous system (CNS) of mammals is highly limited,
creating substantial barriers to recovery after nerve injuries such as optic neuropathies. In …

Dimerization mechanism of an inverted-topology ion channel in membranes Page 1 Washington
University School of Medicine Digital Commons@Becker 2020-Current year OA Pubs Open …