Tocopherols and tocotrienols—bioactive dietary compounds; what is certain, what is doubt?

K Szewczyk, A Chojnacka, M Górnicka - International journal of molecular …, 2021 - mdpi.com
Tocopherols and tocotrienols are natural compounds of plant origin, available in the nature.
They are supplied in various amounts in a diet, mainly from vegetable oils, some oilseeds …

Pharmacology and pharmacokinetics of vitamin E: Nanoformulations to enhance bioavailability

AS Mohd Zaffarin, SF Ng, MH Ng… - International journal of …, 2020 - Taylor & Francis
Vitamin E belongs to the family of lipid-soluble vitamins and can be divided into two groups,
tocopherols and tocotrienols, with four isomers (alpha, beta, gamma and delta). Although …

Japan Atherosclerosis Society (JAS) Guidelines for prevention of atherosclerotic cardiovascular diseases 2022

T Okamura, K Tsukamoto, H Arai, Y Fujioka… - … of Atherosclerosis and …, 2024 - jstage.jst.go.jp
In Japan, a super-aged society, deaths from atherosclerotic cardiovascular disease
(ASCVD), especially cardiac diseases including coronary artery disease (CAD) such as …

Therapeutic potential of palm oil vitamin E-derived tocotrienols in inflammation and chronic diseases: Evidence from preclinical and clinical studies

Z Zainal, H Khaza'ai, AK Radhakrishnan… - Food Research …, 2022 - Elsevier
Palm oil is rich in tocotrienols (T3s), a type of vitamin E that has garnered considerable
research interest as it exhibits anti-inflammatory as well as antioxidant characteristics that …

Molecular mechanism of tocotrienol-mediated anticancer properties: a systematic review of the involvement of endoplasmic reticulum stress and unfolded protein …

KL Pang, CW Mai, KY Chin - Nutrients, 2023 - mdpi.com
Background: Tocotrienol, a type of vitamin E, is well known for its anti-cancer and other
biological activities. This systematic review aims to summarize the involvement of …

Optimization of high-efficient pre-column sample treatments and C18-UFLC method for selective quantification of selected chemical forms of tocopherol and …

M Czauderna, W Wojtak, M Białek, A Białek - Food Chemistry, 2024 - Elsevier
The improved pre-column methods followed by gradient elution C18-chromatography (C18-
UFLC) with photodiode (DAD) and fluorescence (FLD) detection for analysis of tocotrienols …

[HTML][HTML] Therapeutic potential of annatto tocotrienol with self-emulsifying drug delivery system in a rat model of postmenopausal bone loss

NV Mohamad, S Ima-Nirwana, KY Chin - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Tocotrienol has been shown to prevent bone loss in animal models of postmenopausal
osteoporosis, but the low oral bioavailability might limit its use. A self-emulsifying drug …

[HTML][HTML] Effects of emulsified and non-emulsified palm tocotrienol on bone and joint health in ovariectomised rats with monosodium iodoacetate-induced osteoarthritis

SO Ekeuku, MLN Muhamad, AA Aminuddin… - Biomedicine & …, 2024 - Elsevier
Postmenopausal women are susceptible to osteoporosis and osteoarthritis. Tocotrienol, a
bone-protective nutraceutical, is reported to prevent osteoarthritis in male rats. However, its …

[HTML][HTML] Rice bran, an off-shoot to newer therapeutics in neurological disorders

T Behl, S Kumar, A Sehgal, S Singh, S Kumari… - Biomedicine & …, 2021 - Elsevier
Normal brain functioning involves the interaction of interconnected molecular and cellular
activities, which appear to alter normal to abnormal brain functioning when worsened …

Tocotrienol as a protecting agent against glucocorticoid-induced osteoporosis: a mini review of potential mechanisms

SO Ekeuku, ES Mohd Ramli, N Abdullah Sani… - Molecules, 2022 - mdpi.com
Glucocorticoid-induced osteogenic dysfunction is the main pathologyical mechanism
underlying the development of glucocorticoid-induced osteoporosis. Glucocorticoids …