Long non-coding RNAs in lung cancer: Unraveling the molecular modulators of MAPK signaling

MS Hussain, O Afzal, G Gupta, ASA Altamimi… - … -Research and Practice, 2023 - Elsevier
Lung cancer (LC) continues to pose a significant global medical burden, necessitating a
comprehensive understanding of its molecular foundations to establish effective treatment …

The lncRNA epigenetics: the significance of m6A and m5C lncRNA modifications in cancer

VY Cusenza, A Tameni, A Neri, R Frazzi - Frontiers in oncology, 2023 - frontiersin.org
Most of our transcribed RNAs are represented by non-coding sequences. Long non-coding
RNAs (lncRNAs) are transcripts with no or very limited protein coding ability and a length> …

RNA: The Unsuspected Conductor in the Orchestra of Macromolecular Crowding

E Zacco, L Broglia, M Kurihara, M Monti… - Chemical …, 2024 - ACS Publications
This comprehensive Review delves into the chemical principles governing RNA-mediated
crowding events, commonly referred to as granules or biological condensates. We explore …

Connecting the dots: LncRNAs in the KRAS pathway and cancer

M Maqbool, MS Hussain, AS Bisht, A Kumari… - … -Research and Practice, 2024 - Elsevier
Long non-coding RNAs (lncRNAs) have been identified as important participants in several
biological functions, particularly their complex interactions with the KRAS pathway, which …

Liquid–liquid phase separation in diseases

X Zhang, L Yuan, W Zhang, Y Zhang, Q Wu, C Li… - MedComm, 2024 - Wiley Online Library
Liquid–liquid phase separation (LLPS), an emerging biophysical phenomenon, can
sequester molecules to implement physiological and pathological functions. LLPS …

RPS 2.0: an updated database of RNAs involved in liquid–liquid phase separation

Y He, X Bao, T Chen, Q Jiang, L Zhang… - Nucleic Acids …, 2025 - academic.oup.com
Liquid–liquid phase separation (LLPS) is a crucial process for the formation of biomolecular
condensates such as coacervate droplets, P-bodies and stress granules, which play critical …

The role of phase separation in RNA modification: Both cause and effect

Y Lu, L Gan, S Di, F Nie, H Shi, R Wang, F Yang… - International Journal of …, 2024 - Elsevier
Phase separation is a critical mechanism for partitioning cellular functions by specific
aggregation of biological macromolecules. Recent studies have found that phase separation …

Rationalizing the effects of RNA modifications on protein interactions

A Vandelli, L Broglia, A Armaos, RD Ponti… - … Therapy Nucleic Acids, 2024 - cell.com
RNA modifications play a crucial role in regulating gene expression by altering RNA
structure and modulating interactions with RNA-binding proteins (RBPs). In this study, we …