[HTML][HTML] Navigating multi-scale cancer systems biology towards model-driven clinical oncology and its applications in personalized therapeutics
MN Gondal, SU Chaudhary - Frontiers in Oncology, 2021 - frontiersin.org
Rapid advancements in high-throughput omics technologies and experimental protocols
have led to the generation of vast amounts of scale-specific biomolecular data on cancer …
have led to the generation of vast amounts of scale-specific biomolecular data on cancer …
Workflow-driven clinical decision support for personalized oncology
A Bucur, J van Leeuwen, N Christodoulou… - BMC medical informatics …, 2016 - Springer
Background The adoption in oncology of Clinical Decision Support (CDS) may help clinical
users to efficiently deal with the high complexity of the domain, lead to improved patient …
users to efficiently deal with the high complexity of the domain, lead to improved patient …
Dendritic cell vaccination for glioblastoma multiforme: review with focus on predictive factors for treatment response
J Dejaegher, S Van Gool… - ImmunoTargets and …, 2014 - Taylor & Francis
Glioblastoma multiforme (GBM) is the most common and most aggressive type of primary
brain cancer. Since median overall survival with multimodal standard therapy is only 15 …
brain cancer. Since median overall survival with multimodal standard therapy is only 15 …
Theoretical evaluation of the impact of diverse treatment conditions by calculation of the tumor control probability (TCP) of simulated cervical cancer Hyperthermia …
S Mingo Barba, A Ademaj, D Marder… - International Journal …, 2024 - Taylor & Francis
Introduction Hyperthermia (HT) induces various cellular biological processes, such as repair
impairment and direct HT cell killing. In this context, in-silico biophysical models that …
impairment and direct HT cell killing. In this context, in-silico biophysical models that …
[HTML][HTML] A multidisciplinary hyper-modeling scheme in personalized in silico oncology: coupling cell kinetics with metabolism, signaling networks, and biomechanics …
The massive amount of human biological, imaging, and clinical data produced by multiple
and diverse sources necessitates integrative modeling approaches able to summarize all …
and diverse sources necessitates integrative modeling approaches able to summarize all …
In Silico Oncology: Quantification of the In Vivo Antitumor Efficacy of Cisplatin-Based Doublet Therapy in Non-Small Cell Lung Cancer (NSCLC) through a Multiscale …
E Kolokotroni, D Dionysiou, C Veith… - PLoS Computational …, 2016 - journals.plos.org
The 5-year survival of non-small cell lung cancer patients can be as low as 1% in advanced
stages. For patients with resectable disease, the successful choice of preoperative …
stages. For patients with resectable disease, the successful choice of preoperative …
Adaptive mathematical model of tumor response to radiotherapy based on CBCT data
A Belfatto, M Riboldi, D Ciardo… - IEEE journal of …, 2015 - ieeexplore.ieee.org
Mathematical modeling of tumor response to radiotherapy has the potential of enhancing the
quality of the treatment plan, which can be even tailored on an individual basis. Lack of …
quality of the treatment plan, which can be even tailored on an individual basis. Lack of …
Differentiation resistance through altered retinoblastoma protein function in acute lymphoblastic leukemia: in silico modeling of the deregulations in the G1/S restriction …
Background As in many cancer types, the G1/S restriction point (RP) is deregulated in Acute
Lymphoblastic Leukemia (ALL). Hyper-phosphorylated retinoblastoma protein (hyper-pRb) …
Lymphoblastic Leukemia (ALL). Hyper-phosphorylated retinoblastoma protein (hyper-pRb) …
化疗对于肾母细胞瘤肺转移灶的疗效观察
石艳， 杨猛， 黄一天， 许俊杰， 温晟， 何大维… - 临床儿科 …, 2022 - jcp.xinhuamed.com.cn
目的观察肾母细胞瘤(WT) 肺转移灶的转归, 探讨不同化疗方案的疗效. 方法回顾性分析2012
年至2020 年就诊并规律随访的WT 肺转移患儿的临床资料, 分析肿瘤肺转移灶对不同化疗的 …
年至2020 年就诊并规律随访的WT 肺转移患儿的临床资料, 分析肿瘤肺转移灶对不同化疗的 …
Navigating Multi-scale Cancer Systems Biology towards Model-driven Personalized Therapeutics
MN Gondal, SU Chaudhary - bioRxiv, 2021 - biorxiv.org
Rapid advancements in high-throughput omics technologies and experimental protocols
have led to the generation of vast amounts of biomolecular data on cancer that now …
have led to the generation of vast amounts of biomolecular data on cancer that now …