Metallodrugs in medicinal inorganic chemistry

KD Mjos, C Orvig - Chemical reviews, 2014 - ACS Publications
Metal ions play important roles in biological processes, 1 and the field of knowledge
concerned with the application of inorganic chemistry to therapy or diagnosis of disease is …

Recent advances in porphyrin-based MOFs for cancer therapy and diagnosis therapy

Z Wang, Q Sun, B Liu, Y Kuang, A Gulzar, F He… - Coordination Chemistry …, 2021 - Elsevier
Porphyrins and porphyrin derivatives have attracted significant interest in the fields of
catalysis, biosensing, gas storage, solar cells, and biomedical applications owing to their …

Recent development of luminescent rhenium (I) tricarbonyl polypyridine complexes as cellular imaging reagents, anticancer drugs, and antibacterial agents

LCC Lee, KK Leung, KKW Lo - Dalton Transactions, 2017 - pubs.rsc.org
There has been fast-growing interest in the exploitation of the photophysical and
photochemical properties of luminescent transition metal complexes in biological …

Bifunctional coupling agents for radiolabeling of biomolecules and target-specific delivery of metallic radionuclides

S Liu - Advanced drug delivery reviews, 2008 - Elsevier
Receptor-based radiopharmaceuticals are of great current interest in molecular imaging and
radiotherapy of cancers, and provide a unique tool for target-specific delivery of …

Technetium and gallium derived radiopharmaceuticals: comparing and contrasting the chemistry of two important radiometals for the molecular imaging era

MD Bartholoma, AS Louie, JF Valliant… - Chemical …, 2010 - ACS Publications
The objective of medical imaging using molecular probes and perfusion radiotracers is to
provide rapid, noninvasive evaluation of physiology, pathology, and/or organ function. The …

Synthesis and evaluation of technetium-99m-and rhenium-labeled inhibitors of the prostate-specific membrane antigen (PSMA)

SR Banerjee, CA Foss, M Castanares… - Journal of medicinal …, 2008 - ACS Publications
The prostate-specific membrane antigen (PSMA) is increasingly recognized as a viable
target for imaging and therapy of cancer. We prepared seven 99mTc/Re-labeled compounds …

“Click to chelate”: synthesis and installation of metal chelates into biomolecules in a single step

TL Mindt, H Struthers, L Brans, T Anguelov… - Journal of the …, 2006 - ACS Publications
Click chemistry has been employed for the assembly of novel and efficient triazole-based
multidentate chelating systems while simultaneously attaching them to molecules of …

PET/SPECT imaging agents for neurodegenerative diseases

L Zhu, K Ploessl, HF Kung - Chemical Society Reviews, 2014 - pubs.rsc.org
Single photon emission computed tomography (SPECT) or positron emission computed
tomography (PET) imaging agents for neurodegenerative diseases have a significant impact …

Metallic radionuclides in the development of diagnostic and therapeutic radiopharmaceuticals

S Bhattacharyya, M Dixit - Dalton transactions, 2011 - pubs.rsc.org
Metallic radionuclides are the mainstay of both diagnostic and therapeutic
radiopharmaceuticals. Therapeutic nuclear medicine is less advanced but has tremendous …

“Click‐to‐chelate”: design and incorporation of triazole‐containing metal‐chelating systems into biomolecules of diagnostic and therapeutic interest

H Struthers, B Spingler, TL Mindt… - Chemistry–A European …, 2008 - Wiley Online Library
The site‐specific conjugation of metal chelating systems to biologically relevant molecules is
an important contemporary topic in bioinorganic and bioorganometallic chemistry. In this …