Genetic studies suggest that sequential dissemination from a primary metastasis, usually at
the bone, is a major route of metastatic progression in early, radically resected cancer …

Metastasis is the major cause of cancer-related deaths due to the lack of effective therapies.
Emerging evidence suggests that certain epigenetic and transcriptional regulators drive …

A significant proportion of patients with oestrogen receptor (ER) positive breast cancers (BC)
develop resistance to endocrine treatments (ET) and relapse with metastatic disease. Here …

Background Tamoxifen treatment of estrogen receptor (ER)-positive breast cancer reduces
mortality by 31%. However, over half of advanced ER-positive breast cancers are …

For many patients with breast cancer, symptomatic bone metastases appear after years of
latency. How micrometastatic lesions remain dormant and undetectable before initiating …

Breast cancer remains a major health issue in the world with 1.7 million new cases in 2012
worldwide. It is the second cause of death from cancer in western countries. Genomics have …

Background Dormant estrogen receptor positive (ER+) breast cancer micrometastases in the
bone marrow survive adjuvant chemotherapy and recur stochastically for more than 20 …

The histone H3 lysine 4‐specific methyltransferase SETD1A is associated with transcription
activation and is considered a key epigenetic regulator that modulates the cell cycle and …

Background The use of biomarkers that allow early therapeutic intervention or intensive
follow-up evaluation is expected to be a powerful means for reducing breast cancer …

Background The liver ranks as the sixth most prevalent site of primary cancer in humans,
and it frequently experiences metastases from cancers originating in other organs. To …