The trans-Golgi network (TGN) is an important cargo sorting station within the cell where
newly synthesized proteins are packaged into distinct transport carriers that are targeted to …

Polarized cells such as epithelial cells and neurons exhibit different plasma membrane
domains with distinct protein compositions. Recent studies have shown that sorting of …

Epithelial cells have an apical–basolateral axis of polarity, which is required for epithelial
functions including barrier formation, vectorial ion transport and sensory perception. Here …

The clathrin adaptor protein complex-1 (AP-1) is a central player in cell physiology and
human health. It is best known for its role in linking clathrin to its cargo at the trans-Golgi …

Cadherin-based adherens junctions are conserved structures that mediate epithelial cell–
cell adhesion in invertebrates and vertebrates. Despite their pivotal function in epithelial …

Several mechanisms allow for cargo internalization into cells within membrane-bound
endocytic carriers. How these internalization processes couple to specific pathways of …

The contents of numerous membrane lipids change upon ageing. However, it is unknown
whether and how any of these changes are causally linked to lifespan regulation. Acyl …

In epithelial cells, the polarized orientation of the apical–basal axis determines the position
of the apical lumen and, thereby, the collective tubular tissue architecture. From recent …

The counterbalancing action of the endocytosis and secretory pathways maintains a
dynamic equilibrium that regulates the composition of the plasma membrane, allowing it to …

Toll-like receptors (TLRs) are membrane-bound microbial sensors that mediate important
host-to-microbe responses. Cell biology aspects of TLR function have been intensively …