Genetic and molecular epidemiology of adult diffuse glioma

AM Molinaro, JW Taylor, JK Wiencke… - Nature Reviews …, 2019 - nature.com
The WHO 2007 glioma classification system (based primarily on tumour histology) resulted
in considerable interobserver variability and substantial variation in patient survival within …

Risk factors for childhood and adult primary brain tumors

QT Ostrom, M Adel Fahmideh, DJ Cote… - Neuro …, 2019 - academic.oup.com
Primary brain tumors account for~ 1% of new cancer cases and~ 2% of cancer deaths in the
United States; however, they are the most commonly occurring solid tumors in children …

Genome-wide association studies of cancer: current insights and future perspectives

A Sud, B Kinnersley, RS Houlston - Nature Reviews Cancer, 2017 - nature.com
Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …

Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors

BS Melin, JS Barnholtz-Sloan, MR Wrensch… - Nature …, 2017 - nature.com
Genome-wide association studies (GWAS) have transformed our understanding of glioma
susceptibility, but individual studies have had limited power to identify risk loci. We …

Epidemiology of brain tumors

JS Barnholtz-Sloan, QT Ostrom… - Neurologic …, 2018 - neurologic.theclinics.com
Brain and central nervous system (CNS) tumors represent approximately 1% of all newly
diagnosed cancers in the United States, and about 2% of cancer deaths. 1, 2 These are a …

Global incidence of malignant brain and other central nervous system tumors by histology, 2003–2007

R Leece, J Xu, QT Ostrom, Y Chen, C Kruchko… - Neuro …, 2017 - academic.oup.com
Background Previous reports have shown that overall incidence of malignant brain and
other central nervous system (CNS) tumors varied significantly by country. The aim of this …

Common genetic variation influencing human white matter microstructure

B Zhao, T Li, Y Yang, X Wang, T Luo, Y Shan, Z Zhu… - Science, 2021 - science.org
INTRODUCTION White matter in the human brain serves a critical role in organizing
distributed neural networks. Diffusion magnetic resonance imaging (dMRI) has enabled the …

Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis

CS Gallagher, N Mäkinen, HR Harris… - Nature …, 2019 - nature.com
Uterine leiomyomata (UL) are the most common neoplasms of the female reproductive tract
and primary cause for hysterectomy, leading to considerable morbidity and high economic …

Association analyses identify 31 new risk loci for colorectal cancer susceptibility

PJ Law, M Timofeeva, C Fernandez-Rozadilla… - Nature …, 2019 - nature.com
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a
strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases …

International patterns and trends in the brain cancer incidence and mortality: An observational study based on the global burden of disease

I Ilic, M Ilic - Heliyon, 2023 - cell.com
Background Brain cancer is a serious issue in the global burden of diseases. This
observational research aimed to assess trends of the brain cancer incidence and mortality in …