The purpose of this work is to review the published studies on the mechanisms of action and
resistance of 5-fluorouracil. The review is divided into three main sections: mechanisms of …

Amyloid-β precursor protein (APP) is a membrane-spanning protein with a large
extracellular domain and a much smaller intracellular domain. It is the source of the amyloid …

Background Increased total tau (t-tau) in cerebrospinal fluid (CSF) is a key characteristic of
Alzheimer's disease (AD) and is considered to result from neurodegeneration. T-tau levels …

There are many lines of evidence showing that oxidative stress and aberrant mitogenic
changes have important roles in the pathogenesis of Alzheimer's disease (AD). However …

Proteolytic processing of the amyloid‐β precursor protein (APP) generates the Aβ amyloid
peptide of Alzheimer's disease. The biological function of APP itself remains, however …

Since the discovery of the amyloid precursor protein (APP) in 1987, extensive research has
been conducted analyzing the APP-derived β-amyloid (Aβ) which is found in massive …

Abstract The FE65s (FE65, FE65L1, and FE65L2) are a family of multidomain adaptor
proteins that form multiprotein complexes with a range of functions. FE65 is brain‐enriched …

Alzheimer's disease (AD) is the most common neurodegenerative disease with tens of
millions of people affected worldwide. The pathogenesis is still poorly understood and …

Transcription factor CP2c (also known as TFCP2, α-CP2, LSF, and LBP-1c) is involved in
diverse ubiquitous and tissue/stage-specific cellular processes and in human malignancies …

Polymorphic genes associated with Alzheimer's disease (see) delineate a clearly defined
pathway related to cerebral and peripheral cholesterol and lipoprotein homoeostasis. They …