Recent advances on the molecular mechanisms of exercise-induced improvements of cognitive dysfunction

Y Lu, FQ Bu, F Wang, L Liu, S Zhang, G Wang… - Translational …, 2023 - Springer
Physical exercise is of great significance for maintaining human health. Exercise can
provide varying degrees of benefits to cognitive function at all stages of life cycle. Currently …

Surgery, neuroinflammation and cognitive impairment

A Alam, Z Hana, Z Jin, KC Suen, D Ma - EBioMedicine, 2018 - thelancet.com
Trauma experienced during surgery can contribute to the development of a systemic
inflammatory response that can cause multi-organ dysfunction or even failure. Post-surgical …

Sepsis-associated encephalopathy and septic encephalitis: an update

SC Tauber, M Djukic, J Gossner, H Eiffert… - Expert review of anti …, 2021 - Taylor & Francis
Introduction Sepsis-associated encephalopathy (SAE) and septic encephalitis (SE) are
associated with increased mortality, long-term cognitive impairment, and focal neurological …

The relationship between inflammation and neurocognitive dysfunction in obstructive sleep apnea syndrome

X Liu, Y Ma, R Ouyang, Z Zeng, Z Zhan, H Lu… - Journal of …, 2020 - Springer
Obstructive sleep apnea syndrome (OSAS), a state of sleep disorder, is characterized by
repetitive apnea, chronic hypoxia, oxygen desaturation, and hypercapnia. Previous studies …

Dexmedetomidine ameliorates acute stress‐induced kidney injury by attenuating oxidative stress and apoptosis through inhibition of the ROS/JNK signaling pathway

Y Chen, X Feng, X Hu, J Sha, B Li… - … medicine and cellular …, 2018 - Wiley Online Library
Acute stress induces tissue damage through excessive oxidative stress. Dexmedetomidine
(DEX) reportedly has an antioxidant effect. However, protective roles and related potential …

The potential role of dexmedetomidine on neuroprotection and its possible mechanisms: Evidence from in vitro and in vivo studies

K Unchiti, P Leurcharusmee… - European Journal of …, 2021 - Wiley Online Library
Neurological disorders following brain injuries and neurodegeneration are on the rise
worldwide and cause disability and suffering in patients. It is crucial to explore novel …

Catalytic nanozymes for central nervous system disease

K Chen, S Sun, J Wang, XD Zhang - Coordination Chemistry Reviews, 2021 - Elsevier
The central nervous system (CNS) is a centralized control system for the human body, and
minor lesions or injuries will cause inestimable consequences. Due to high oxygen …

Recombinant CC16 inhibits NLRP3/caspase-1-induced pyroptosis through p38 MAPK and ERK signaling pathways in the brain of a neonatal rat model with sepsis

R Zhou, X Yang, X Li, Y Qu, Q Huang, X Sun… - Journal of …, 2019 - Springer
Background Sepsis is a critical disease associated with extremely high mortality. Some
severe forms of sepsis can induce brain injury, thus causing behavioral and cognitive …

Dexmedetomidine ameliorates postoperative cognitive dysfunction in aged mice

X Xie, Z Shen, C Hu, K Zhang, M Guo, F Wang… - Neurochemical …, 2021 - Springer
Neuroinflammation and oxidative stress coexist and interact in the progression of
postoperative cognitive dysfunction (POCD) and other neurodegenerative disease …

Cellular senescence as a key contributor to secondary neurodegeneration in traumatic brain injury and stroke

Z Huang, P Xu, DC Hess, Q Zhang - Translational Neurodegeneration, 2024 - Springer
Traumatic brain injury (TBI) and stroke pose major health challenges, impacting millions of
individuals globally. Once considered solely acute events, these neurological conditions are …