This review considers the relationship between the lifespan of an individual plant and the
longevity of its component cells, tissues and organs. It begins by defining the terms …

Telomeres play a central role in cell fate and aging by adjusting the cellular response to
stress and growth stimulation on the basis of previous cell divisions and DNA damage. At …

Telomeres allow cells to distinguish natural chromosome ends from damaged DNA. When
telomere function is disrupted, a potentially lethal DNA damage response can ensue, DNA …

Alternative lengthening of telomeres (ALT) involves homology-directed telomere synthesis.
This multistep process is facilitated by loss of the ATRX or DAXX chromatin-remodeling …

Background: Genetic instability associated with telomere dysfunction (ie, short telomeres) is
an early event in tumorigenesis. We investigated the association between telomere length …

Plant growth and development are driven by the continuous generation of new cells.
Whereas much has been learned at a molecular level about the mechanisms that …

Orthologs of the yeast telomere protein Stn1 are present in plants, but other components of
the Cdc13/Stn1/Ten1 (CST) complex have only been found in fungi. Here we report the …

Telomerase is a ribonucleoprotein complex that catalyses the addition of TTAGGG repeats
onto telomeres, repetitive DNA structures found at the ends of linear chromosomes. The …

Ataxia telangiectasia-mutated and Rad3-related (ATR) plays a central role in cell-cycle
regulation, transmitting DNA damage signals to downstream effectors of cell-cycle …

Spaceflight-induced changes in astronaut telomeres have garnered significant attention in
recent years. While plants represent an essential component of future long-duration space …