Neuropeptide regulation of fear and anxiety: Implications of cholecystokinin, endogenous opioids, and neuropeptide Y

ME Bowers, DC Choi, KJ Ressler - Physiology & behavior, 2012 - Elsevier
The neural circuitry of fear likely underlies anxiety and fear-related disorders such as
specific and social phobia, panic disorder, and posttraumatic stress disorder. The primary …

[HTML][HTML] Targeting the neuropeptide Y system in stress-related psychiatric disorders

NM Enman, EL Sabban, P McGonigle… - Neurobiology of …, 2015 - Elsevier
Repeated, extreme, or traumatic stressors can elicit pathological effects leading to many
negative physical and psychological outcomes. Stressors can precipitate the onset of …

Single intranasal neuropeptide Y infusion attenuates development of PTSD-like symptoms to traumatic stress in rats

LI Serova, A Tillinger, LG Alaluf, M Laukova, K Keegan… - Neuroscience, 2013 - Elsevier
Exposure to severe stress leads to development of neuropsychiatric disorders, including
depression and Post-Traumatic Stress Disorder (PTSD) in at-risk individuals. Neuropeptide …

[HTML][HTML] The role of Neuropeptide Y in fear conditioning and extinction

RO Tasan, D Verma, J Wood, G Lach, B Hörmer… - Neuropeptides, 2016 - Elsevier
While anxiety disorders are the brain disorders with the highest prevalence and constitute a
major burden for society, a considerable number of affected people are still treated …

Neuropeptide Y (NPY) gene: Impact on emotional processing and treatment response in anxious depression

K Domschke, U Dannlowski, C Hohoff… - European …, 2010 - Elsevier
Neuropeptide Y (NPY) has been found to play a role in the pathomechanism of both anxiety
and depression. Thus, NPY is a promising candidate in the investigation of the clinical …

[HTML][HTML] Genetic strain differences in learned fear inhibition associated with variation in neuroendocrine, autonomic, and amygdala dendritic phenotypes

MC Camp, KP MacPherson, L Lederle… - …, 2012 - nature.com
Mood and anxiety disorders develop in some but not all individuals following exposure to
stress and psychological trauma. However, the factors underlying individual differences in …

Anxiolytic-like actions of centrally-administered neuropeptide Y, but not galanin, in C57BL/6J mice

RM Karlsson, A Holmes, M Heilig… - … Biochemistry and Behavior, 2005 - Elsevier
Neuropeptide Y (NPY) and galanin (GAL) are densely localized in brain regions subserving
stress, fear and anxiety. While previous research supports a role for both neuropeptides in …

[HTML][HTML] Animal models of nicotine exposure: relevance to second-hand smoking, electronic cigarette use, and compulsive smoking

A Cohen, O George - Frontiers in psychiatry, 2013 - frontiersin.org
Much evidence indicates that individuals use tobacco primarily to experience the
psychopharmacological properties of nicotine and that a large proportion of smokers …

Viral vector-induced amygdala NPY overexpression reverses increased alcohol intake caused by repeated deprivations in Wistar rats

A Thorsell, V Repunte-Canonigo, LE O'Dell, SA Chen… - Brain, 2007 - academic.oup.com
Acute administration of neuropeptide Y (NPY) modulates alcohol intake in genetic and
chemical models of high intake, while leaving intake unaffected during 'normal'or baseline …

5-HT1A and 5-HT7 receptor crosstalk in the regulation of emotional memory: implications for effects of selective serotonin reuptake inhibitors

TM Eriksson, S Holst, TL Stan, T Hager, B Sjögren… - …, 2012 - Elsevier
This study utilized pharmacological manipulations to analyze the role of direct and indirect
activation of 5-HT7 receptors (5-HT7Rs) in passive avoidance learning by assessing …