The art of finding the right drug target: emerging methods and strategies

ZC Jia, X Yang, YK Wu, M Li, D Das, MX Chen… - Pharmacological …, 2024 - Elsevier
Drug targets are specific molecules in biological tissues and body fluids that interact with
drugs. Drug target discovery is a key component of drug discovery and is essential for the …

[HTML][HTML] Peptide nanozymes: An emerging direction for functional enzyme mimics

S He, L Ma, Q Zheng, Z Wang, W Chen, Z Yu, X Yan… - Bioactive Materials, 2024 - Elsevier
The abundance of molecules on early Earth likely enabled a wide range of prebiotic
chemistry, with peptides playing a key role in the development of early life forms and the …

An in-situ peptide-antibody self-assembly to block CD47 and CD24 signaling enhances macrophage-mediated phagocytosis and anti-tumor immune responses

W Zhang, Y Zeng, Q Xiao, Y Wu, J Liu, H Wang… - Nature …, 2024 - nature.com
Targeted immunomodulation for reactivating innate cells, especially macrophages, holds
great promise to complement current adaptive immunotherapy. Nevertheless, there is still a …

Polyoxometalate‐Nanozyme‐Integrated Nanomotors (POMotors) for Self‐Propulsion‐Promoted Synergistic Photothermal‐Catalytic Tumor Therapy

M Tang, J Ni, Z Yue, T Sun, C Chen, X Ma… - Angewandte …, 2024 - Wiley Online Library
Enzyme‐powered nanomotors have demonstrated promising potential in biomedical
applications, especially for catalytic tumor therapy, owing to their ability of self‐propulsion …

A Transformable Supramolecular Bispecific Cell Engager for Augmenting Natural Killer and T Cell‐Based Cancer Immunotherapy

Y Chen, W Li, Z Wang, Y Yu, J Li, Y Ding… - Advanced …, 2024 - Wiley Online Library
Immune cells are pivotal in cancer immunotherapy, yet their therapeutic effectiveness is
often hampered by limited tumor infiltration and inhibitory tumor microenvironments. An …

Intracellularly Synthesized Artificial Exosome Treats Acute Lung Injury

L Liang, W Peng, A Qin, J Zhang, R Chen, D Zhou… - ACS …, 2024 - ACS Publications
Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS),
induce high morbidity and mortality rates, which challenge the present approaches for the …

Injectable smart stimuli-responsive hydrogels: pioneering advancements in biomedical applications

J Liu, C Du, W Huang, Y Lei - Biomaterials Science, 2024 - pubs.rsc.org
Hydrogels have established their significance as prominent biomaterials within the realm of
biomedical research. However, injectable hydrogels have garnered greater attention …

Application of adhesives in the treatment of cartilage repair

H Feng, K Ang, P Guan, J Li, H Meng… - Interdisciplinary …, 2024 - Wiley Online Library
From degeneration causing intervertebral disc issues to trauma‐induced meniscus tears,
diverse factors can injure the different types of cartilage. This review highlights adhesives as …

Specific interaction based drug loading strategies

H Yu, S Zhang, H Yang, J Miao, X Ma, W Xiong… - Nanoscale …, 2023 - pubs.rsc.org
Drug carriers have been commonly used for drug control release, enhancing drug efficacy
and/or minimizing side-effects. However, it is still difficult to get a high loading efficiency …

[PDF][PDF] Chronobiology of the tumor microenvironment: implications for therapeutic strategies and circadian-based interventions

D Li, Q Yu, R Wu, Z Tuo, W Zhu, J Wang, F Shao… - Aging Dis, 2024 - scholar.archive.org
Numerous research works have emphasized the critical role that circadian rhythm plays in
the tumor microenvironment (TME). The goal of clarifying chrono-pharmacological strategies …