Suppressing inflammation has been the primary focus of therapies in autoimmune rheumatic
diseases (AIRDs), including rheumatoid arthritis and systemic lupus erythematosus …

Lipid metabolism reprogramming is an important hallmark of tumor progression. Cancer
cells require high levels of lipid synthesis and uptake not only to support their continued …

Chemotherapy has an essential role not only in advanced solid tumor therapy intervention
but also in society's health at large. Chemoresistance, however, seriously restricts the …

Temozolomide (TMZ) is considered a first line chemotherapy drug for glioblastoma (GBM).
Unfortunately, the GBM without methylation of O6-methylguanine-DNA methyltransferase …

Background Hepatocellular carcinoma (HCC) remains difficult to treat due to limited effective
treatment options. While the proteasome inhibitor bortezomib has shown promising …

Uncontrolled autophagy has been associated with the development and progression of
various cancers that are resistant to cancer therapy. Therefore, many efforts to modulate …

The intricate cross-talks between tumor cells and their microenvironment play a key role in
cancer progression and resistance to treatment. In recent years, targeting pro-tumorigenic …

High-grade gliomas represent the most common group of infiltrative primary brain tumors in
adults associated with high invasiveness, agressivity, and resistance to therapy, which …

Paneth cells (PCs), a subset of intestinal epithelial cells (IECs) found at the base of small
intestinal crypts, play an essential role in maintaining intestinal homeostasis. Altered PCs …

Glioblastoma multiforme (GBM) is a highly aggressive primary brain tumor. Recent findings
highlighted the significance of viral microRNAs (miRs) in regulating post-transcriptional …