Background Subthreshold depression is highly prevalent in adolescence, but compared to
major depressive disorder, the clinical impact is under-researched. The aim of this review …

Methyl donors such as choline, betaine, folic acid, methionine, and vitamins B6 and B12 are
critical players in the one-carbon metabolism and have neuroprotective functions. The one …

Alongside their function in primary haemostasis and thrombo-inflammation, platelets are
increasingly considered a bridge between mental, immunological and coagulation-related …

Background: Knowledge about the pathogenesis of depression and treatments for this
disease are lacking. Epigenetics-related circRNAs are likely involved in the mechanism of …

Early life stress (ELS), characterized as abuse, neglect, and abandonment, can cause
several adverse consequences in the lives of affected individuals. ELS experiences can …

Background Growing evidence suggests that epigenetic modification is vital in biological
processes of depression. Findings from studies exploring the associations between DNA …

Major depressive disorder (MDD) is the most common psychiatric disorder and responds for
important psychosocial consequences. Stressful life events, especially early life stress …

Theanine, an amino acid unique to tea leaves, has been reported to exhibit stress-relieving
effects. However, the stress-relieving effects of theanine (T) are greatly inhibited by caffeine …

The gut microbiome regulates emotional behavior, stress responses, and inflammatory
processes by communicating with the brain. How and which neurobiological mediators …

Major depressive disorder (MDD) is a prevalent psychiatric disorder that has damage to
people's quality of life. Tryptophan is the precursor to serotonin, a critical neurotransmitter in …