Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …

The mTOR pathway integrates a diverse set of environmental cues, such as growth factor
signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half …

The highly conserved protein kinase mechanistic target of rapamycin (mTOR; originally
known as mammalian target of rapamycin) is a central cell growth regulator connecting …

The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth and
metabolism with environmental inputs, including nutrients and growth factors. Extensive …

The aim of this review was to summarize current available information about the role of
phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling …

In my PNAS Inaugural Article, I describe the development of the mTOR field, starting with
efforts to understand the mechanism of action of the drug rapamycin, which∼ 25 y ago led to …

The mevalonate (MVA) pathway is an essential metabolic pathway that uses acetyl-CoA to
produce sterols and isoprenoids that are integral to tumour growth and progression. In …

KRAS is the most frequently mutated oncogene in human cancer. In addition to holding this
distinction, unsuccessful attempts to target this protein have led to the characterization of …

The mammalian target of rapamycin (mTOR) signaling pathway is a master regulator of cell
growth and metabolism. Deregulation of the mTOR pathway has been implicated in a …

Translation is a key step in the regulation of gene expression and one of the most energy-
consuming processes in the cell. In response to various stimuli, multiple signaling pathways …