C. elegans Apical Extracellular Matrices Shape Epithelia

JD Cohen, MV Sundaram - Journal of developmental biology, 2020 - mdpi.com
Apical extracellular matrices (aECMs) coat exposed surfaces of epithelia to shape
developing tissues and protect them from environmental insults. Despite their widespread …

TGF-β pathways in aging and immunity: lessons from Caenorhabditis elegans

KK Yamamoto, C Savage-Dunn - Frontiers in Genetics, 2023 - frontiersin.org
The Transforming Growth Factor-β (TGF-β) superfamily of signaling molecules plays critical
roles in development, differentiation, homeostasis, and disease. Due to the conservation of …

Unveiling the impact of short-term polyethylene microplastics exposure on metabolomics and gut microbiota in earthworms (Eudrilus euganiae)

WT Chan, CA Medriano, S Bae - Journal of Hazardous Materials, 2023 - Elsevier
Microplastics (MPs) pose a significant environmental concern, particularly for terrestrial
fauna. In this study, earthworms were used as a model organism to investigate the …

Evolution and diversity of TGF-β pathways are linked with novel developmental and behavioral traits

WS Lo, M Roca, M Dardiry, M Mackie… - Molecular Biology …, 2022 - academic.oup.com
Transforming growth factor-β (TGF-β) signaling is essential for numerous biologic functions.
It is a highly conserved pathway found in all metazoans including the nematode …

Rebuilding microbiome for mitigating traumatic brain injury: importance of restructuring the gut-microbiome-brain axis

AK George, J Behera, RP Homme, N Tyagi… - Molecular …, 2021 - Springer
Traumatic brain injury (TBI) is a damage to the brain from an external force that results in
temporary or permanent impairment in brain functions. Unfortunately, not many treatment …

Integrated Analysis of Transcriptome and Metabolome Provides Insight into Camellia oleifera Oil Alleviating Fat Accumulation in High-Fat Caenorhabditis elegans

L Liu, Q Kong, Z Xiang, X Kuang, H Wang… - International Journal of …, 2023 - mdpi.com
Camellia oil (CO) is a high medicinal and nutritional value edible oil. However, its ability to
alleviate fat accumulation in high-fat Caenorhabditis elegans has not been well elucidated …

Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans

L Chauve, F Hodge, S Murdoch, F Masoudzadeh… - PLoS …, 2021 - journals.plos.org
To survive elevated temperatures, ectotherms adjust the fluidity of membranes by fine-tuning
lipid desaturation levels in a process previously described to be cell autonomous. We have …

BMP pathway regulation of insulin signaling components promotes lipid storage in Caenorhabditis elegans

JF Clark, EJ Ciccarelli, P Kayastha, G Ranepura… - PLoS …, 2021 - journals.plos.org
A small number of peptide growth factor ligands are used repeatedly in development and
homeostasis to drive programs of cell differentiation and function. Cells and tissues must …

Membrane Fluidity Is Regulated Cell Nonautonomously by Caenorhabditis elegans PAQR-2 and Its Mammalian Homolog AdipoR2

R Bodhicharla, R Devkota, M Ruiz, M Pilon - Genetics, 2018 - academic.oup.com
The properties of cell membranes are determined mostly by the types of fatty acids that they
contain. Bodhicharla et al. report that a key regulator of membrane fluidity, the PAQR-2/IGLR …

The TGF-β ligand DBL-1 is a key player in a multifaceted probiotic protection against MRSA in C. elegans

MGM Mørch, KV Møller, MO Hesselager… - Scientific Reports, 2021 - nature.com
Worldwide the increase in multi-resistant bacteria due to misuse of traditional antibiotics is a
growing threat for our health. Finding alternatives to traditional antibiotics is thus timely …