Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic
contents to lysosomes for degradation. Genetic studies have revealed extensive links …

Neurodegenerative diseases (NDs) are a wide class of disorders of the central nervous
system (CNS) with unknown etiology. Several factors were hypothesized to be involved in …

Macroautophagy/autophagy, a defense mechanism against aberrant stresses, in neurons
counteracts aggregate-prone misfolded protein toxicity. Autophagy induction might be …

Dysfunction of autophagy, which regulates cellular homeostasis by degrading organelles
and proteins, is associated with pathogenesis of various diseases such as cancer …

In autophagy long‐lived proteins, protein aggregates or damaged organelles are engulfed
by vesicles called autophagosomes prior to lysosomal degradation. Autophagy dysfunction …

The balance between synthesis and degradation is crucial to maintain cellular homeostasis
and different mechanisms are known to keep this balance. In this review, we will provide a …

Prostate cancer (PC) is one of the leading causes of death in males. Available treatments
often lead to the appearance of chemoresistant foci and metastases, with mechanisms still …

Progranulin, a secreted glycoprotein, is encoded in humans by the single GRN gene.
Progranulin consists of seven and a half, tandemly repeated, non-identical copies of the 12 …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two
neurodegenerative diseases in which similar pathogenic mechanisms are involved. Both …

Neurodegenerative diseases (NDs) are often associated with the presence of misfolded
protein inclusions. The chaperone HSPB8 is upregulated in mice, the human brain and …