The COVID-19 pandemic has spurred intense research efforts to identify effective treatments
for SARS-CoV-2. In silico studies have emerged as a powerful tool in the drug discovery …

The COVID-19 pandemic, instigated by the emergence of the novel coronavirus, SARS-CoV-
2, created an incomparable global health crisis. Due to its highly virulent nature, identifying …

The urgency of finding therapeutic solutions for emerging and existing health challenges
has never been more pronounced. In the pursuit of this goal, the value of a strategy that …

The COVID‐19 pandemic continues to pose a substantial threat to human lives and is likely
to do so for years to come. Despite the availability of vaccines, searching for efficient small …

The main protease (M pro) of the novel coronavirus SARS-CoV-2 is a key target for
developing antiviral drugs. Ebselen (EbSe) is a selenium-containing compound that has …

As the world population ages, there will be an increasing need for effective therapies for
aging‐associated neurodegenerative disorders, which remain untreatable. Dementia due to …

Proteases represent common targets in combating infectious diseases, including COVID-19.
The 3-chymotrypsin-like protease (3CLpro) is a validated molecular target for COVID-19 …

Background Riboflavin (vitamin B2) is one of the most important water-soluble vitamins and
a coenzyme involved in many biochemical processes. It has previously been shown that …

Introduction Simnotrelvir is a selective 3-chymotrypsin-like oral protease inhibitor with
activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Areas …

Binding kinetics of drug and its target protein is crucial for the efficacy and safety of the drug.
Using surface plasmon resonance (SPR) technology, we performed a competitive SPR …