In eukaryotic cells, DNA damage can occur at any time and at any chromatin locus, including
loci at which active transcription is taking place. DNA double-strand breaks affect chromatin …

Transcription of actively expressed genes is dampened for kilobases around DNA lesions
via chromatin modifications. This is believed to favour repair and prevent genome instability …

Purpose: Single-cell RNA-sequencing (scRNA-seq) was used to interrogate the relatively
rare stem (SC) and early transit amplifying (TA) cell populations in limbal/corneal epithelia …

Homologous recombination (HR)-based gene therapy using adeno-associated viruses (AAV-
HR) without nucleases has several advantages over classic gene therapy, especially the …

Abstract Sine Oculis Homeobox 1 (SIX1) is a member of homeobox transcription factor
family having pivotal roles in organismal development and differentiation. This protein …

Chromatin remodeler complexes regulate gene transcription, DNA replication and DNA
repair by changing both nucleosome position and post-translational modifications. The …

The effects of genotoxic agents on DNA and the processes involved in their removal have
been thoroughly studied; however, very little is known about the mechanisms governing the …

Abstract The Eyes Absent family (EYA1-4) are a group of dual function proteins that act as
both tyrosine phosphatases and transcriptional co-activators. EYA proteins play a vital role …

Abstract The Eyes Absent (EYA) proteins are the only known instance of a single
polypeptide housing the following three separable biochemical activities: tyrosine …

DNA lesions impact on local transcription and the damage-induced transcriptional
repression facilitates efficient DNA repair. However, how chromatin dynamics cooperates …