Cognitive decline in Parkinson disease
Dementia is a frequent problem encountered in advanced stages of Parkinson disease (PD).
In recent years, research has focused on the pre-dementia stages of cognitive impairment in …
In recent years, research has focused on the pre-dementia stages of cognitive impairment in …
Oxidative stress and cellular pathologies in Parkinson's disease
Parkinson's disease (PD) is a chronic and progressive neurodegeneration of dopamine
neurons in the substantia nigra. The reason for the death of these neurons is unclear; …
neurons in the substantia nigra. The reason for the death of these neurons is unclear; …
The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration
AL Mahul-Mellier, J Burtscher… - Proceedings of the …, 2020 - National Acad Sciences
Parkinson's disease (PD) is characterized by the accumulation of misfolded and aggregated
α-synuclein (α-syn) into intraneuronal inclusions named Lewy bodies (LBs). Although it is …
α-synuclein (α-syn) into intraneuronal inclusions named Lewy bodies (LBs). Although it is …
Are dementia with Lewy bodies and Parkinson's disease dementia the same disease?
KA Jellinger, AD Korczyn - BMC medicine, 2018 - Springer
Abstract Background Dementia with Lewy bodies (DLB) and Parkinson's disease dementia
(PDD), which share many clinical, neurochemical, and morphological features, have been …
(PDD), which share many clinical, neurochemical, and morphological features, have been …
Dementia with Lewy bodies and Parkinson's disease-dementia: current concepts and controversies
KA Jellinger - Journal of neural transmission, 2018 - Springer
Dementia with Lewy bodies (DLB) and Parkinson's disease-dementia (PDD), although
sharing many clinical, neurochemical and morphological features, according to DSM-5, are …
sharing many clinical, neurochemical and morphological features, according to DSM-5, are …
Fluid biomarkers for synaptic dysfunction and loss
E Camporesi, J Nilsson, A Brinkmalm… - Biomarker …, 2020 - journals.sagepub.com
Synapses are the site for brain communication where information is transmitted between
neurons and stored for memory formation. Synaptic degeneration is a global and early …
neurons and stored for memory formation. Synaptic degeneration is a global and early …
Bioactivity of olive oil phenols in neuroprotection
C Angeloni, M Malaguti, MC Barbalace… - International Journal of …, 2017 - mdpi.com
Neurological disorders such as stroke, Alzheimer's and Parkinson's diseases are associated
with high morbidity and mortality, and few or no effective options are available for their …
with high morbidity and mortality, and few or no effective options are available for their …
Synaptic changes in Parkinson disease assessed with in vivo imaging
D Matuskey, S Tinaz, KC Wilcox… - Annals of …, 2020 - Wiley Online Library
Objective Parkinson disease is characterized by motor and nonmotor symptoms, reduced
striatal dopamine signaling, and loss of dopamine neurons in the substantia nigra. It is now …
striatal dopamine signaling, and loss of dopamine neurons in the substantia nigra. It is now …
Synaptic dysfunction in neurodegenerative and neurodevelopmental diseases: an overview of induced pluripotent stem-cell-based disease models
E Taoufik, G Kouroupi, O Zygogianni… - Open …, 2018 - royalsocietypublishing.org
Synaptic dysfunction in CNS disorders is the outcome of perturbations in physiological
synapse structure and function, and can be either the cause or the consequence in specific …
synapse structure and function, and can be either the cause or the consequence in specific …
Changes in synaptic proteins precede neurodegeneration markers in preclinical Alzheimer's disease cerebrospinal fluid
A biomarker of synapse loss, an early event in Alzheimer's disease (AD) pathophysiology
that precedes neuronal death and symptom onset, would be a much-needed prognostic …
that precedes neuronal death and symptom onset, would be a much-needed prognostic …