Accumulating evidence suggests that epigenetic alterations play an important role in
chemically-induced carcinogenesis. Although the epigenome and genome may be equally …

Background Epidemiological studies have found that prenatal exposure to polycyclic
aromatic hydrocarbons (PAHs) is associated with increased risk for neural tube defects …

Novel DNA intercalating anticancer drug curaxin CBL0137 significantly inhibited in vitro
DNA methylation by eukaryotic DNA methyltransferase Dnmt3a catalytic domain (Dnmt3a …

Olivomycin A is a highly active antitumor drug that belongs to the family of aureolic acid
antibiotics. The antitumor effect of olivomycin A is related to its ability to bind to the DNA …

The combined action of reactive metabolites of benzo [a] pyrene (B [a] P) and oxidative
stress can lead to cluster-type DNA damage that includes both a bulky lesion and an …

The incorporation of chemotherapeutic agent 6-thioguanine (SG) into DNA is a prerequisite
for its cytotoxic action. This modification of DNA impedes the activity of enzymes involved in …

Scientific evidence has confirmed that air pollution is associated with several ailments and
some particular toxic pollutants have caused cancer and death. Though anthropogenic …

Оливомицин А является высокоактивным противоопухолевым препаратом,
относящимся к классу антибиотиков группы ауреоловой кислоты (АК) …

Изучено влияние повреждения ДНК бензо [а] пиреном (одним из самых
распространенных канцерогенов) на функционирование укороченной изоформы …

We have studied the impact of DNA damage by one of the most common carcinogens,
benzo [a] pyrene, on the functioning of the truncated isoform of DNA methyltransferase …