As synaptic vesicles fuse, they must continually be replaced with new docked, fusion-
competent vesicles to sustain neurotransmission. It has long been appreciated that vesicles …

Studies on synaptic proteins involved in neurotransmitter release often aim at distinguishing
between their roles in vesicle priming (the docking of synaptic vesicles to the plasma …

The molecular basis of asynchronous neurotransmitter release remains enigmatic despite
decades of intense study. Synaptotagmin (syt) 7 and Doc2 have both been proposed as …

During prolonged trains of presynaptic action potentials (APs), synaptic release reaches a
stable level that reflects the speed of replenishment of the readily releasable pool (RRP) …

The Ca 2+-dependence of the priming, fusion, and replenishment of synaptic vesicles are
fundamental parameters controlling neurotransmitter release and synaptic plasticity. Despite …

The concentration of calcium ions in presynaptic terminals regulates transmitter release, but
underlying mechanisms have remained unclear. Here we review recent studies that shed …

Recent research suggests that in central mammalian synapses, active zones contain several
docking sites acting in parallel. Before release, one or several synaptic vesicles (SVs) are …

Axons are equipped with the digital signaling capacity by which they generate and faithfully
propagate action potentials (APs), and also with the analogue signaling capacity by which …

Before fusion, synaptic vesicles (SVs) pause at discrete release/docking sites. During
repetitive stimulation, the probability of site occupancy changes following SV fusion and …

One of the central goals of neuroscience is to decipher the specific contributions of neural
mechanisms to different aspects of sensory perception. Since achieving this goal requires …