DNA and RNA can fold into a variety of alternative conformations. In recent years, a
particular nucleic acid structure was discussed to play a role in malignant transformation and …

The nuclear transcription factor c-Myc is a member of the Myc gene family with multiple
functions and located on band q24. 1 of chromosome 8. The c-Myc gene is activated by …

Numerous studies have shown that berberine and its derivatives demonstrate important anti-
tumor effects. However, the specific underlying mechanism remains unclear. Therefore …

Introduction: A number of plant-derived agents are used in many therapeutic areas.
Berberine, an important protoberberine alkaloid, is present in a number of medicinal plants …

Cancer is a societal burden demanding innovative approaches. A major problem with the
conventional chemotherapeutic agents is their strong toxicity and other side effects due to …

Telomeres and telomerase are nowadays exploring traits on targets for anticancer therapy.
Telomerase is a unique reverse transcriptase enzyme, considered as a primary factor in …

Overexpression of the MYC oncogene is a molecular hallmark of both cancer initiation and
progression. Targeting MYC is a logical and effective cancer therapeutic strategy. A special …

Conventional chemotherapy remains the primary treatment option for triple-negative breast
cancer (TNBC). However, the current chemotherapeutic drugs have limited effects on TNBC …

Organic small molecules that can recognize and bind to G-quadruplex and i-Motif nucleic
acids have great potential as selective drugs or as tools in drug target discovery programs …

G-quadruplexes (G4s) are higher-order DNA structures typically present at promoter regions
of genes and telomeres. Here, the G4 formation decreases the replicative DNA at each cell …