An enhanced thrombotic environment and premature atherosclerosis are key factors for the
increased cardiovascular risk in diabetes. The occlusive vascular thrombus, formed …

Cardiovascular disease remains the main cause of morbidity and mortality in patients with
diabetes. The risk of vascular ischemia is increased in this population and outcome …

SerpinB2 (plasminogen activator inhibitor type 2) has been called the “undecided serpin”
with no clear consensus on its physiological role, although it is well described as an inhibitor …

There is substantial evidence implicating the urokinase system in tissue remodeling during
neo-vascularization, inflammation, tumor invasion, and metastasis. Regulated degradation …

Serine Protease Inhibitors (Serpins) control tightly regulated physiological processes and
their dysfunction is associated to various diseases. Thus, increasing interest is given to …

Bleeding and thrombotic disorders result from imbalances in coagulation or fibrinolysis,
respectively. Inhibitors from the serine protease inhibitor (serpin) family have a key role in …

The mammalian circadian and sleep-wake systems are closely aligned through their
coordinated regulation of daily activity patterns. Although they differ in their anatomical …

Stressful events trigger a set of complex biological responses which follow a bell-shaped
pattern. Low-stress conditions have been shown to elicit beneficial effects, notably on …

During pregnancy, the vertical transmission of the Zika virus (ZIKV) can cause some
disorders in the fetus, called Congenital Zika Syndrome (CZS). Several efforts have been …

Glycosaminoglycans (GAGs) are very complex, natural anionic polysaccharides. They are
polymers of repeating disaccharide units of uronic acid and hexosamine residues. Owing to …