Hierarchy of RNA functional dynamics
RNA dynamics play a fundamental role in many cellular functions. However, there is no
general framework to describe these complex processes, which typically consist of many …
general framework to describe these complex processes, which typically consist of many …
Of proteins and RNA: the RNase P/MRP family
O Esakova, AS Krasilnikov - Rna, 2010 - rnajournal.cshlp.org
Nuclear ribonuclease (RNase) P is a ubiquitous essential ribonucleoprotein complex, one of
only two known RNA-based enzymes found in all three domains of life. The RNA component …
only two known RNA-based enzymes found in all three domains of life. The RNA component …
Structural insight into precursor tRNA processing by yeast ribonuclease P
P Lan, M Tan, Y Zhang, S Niu, J Chen, S Shi, S Qiu… - Science, 2018 - science.org
INTRODUCTION Ribonuclease P (RNase P), a universal ribozyme that has been found in
organisms from all three domains of life, processes the 5′ end of transfer RNA (tRNA) …
organisms from all three domains of life, processes the 5′ end of transfer RNA (tRNA) …
Characterizing micro-to-millisecond chemical exchange in nucleic acids using off-resonance R1ρ relaxation dispersion
This review describes off-resonance R 1ρ relaxation dispersion NMR methods for
characterizing microsecond-to-millisecond chemical exchange in uniformly 13 C/15 N …
characterizing microsecond-to-millisecond chemical exchange in uniformly 13 C/15 N …
The diversity of ribonuclease P: protein and RNA catalysts with analogous biological functions
Ribonuclease P (RNase P) is an essential endonuclease responsible for catalyzing 5'end
maturation in precursor transfer RNAs. Since its discovery in the 1970s, RNase P enzymes …
maturation in precursor transfer RNAs. Since its discovery in the 1970s, RNase P enzymes …
Insights into Watson–Crick/Hoogsteen breathing dynamics and damage repair from the solution structure and dynamic ensemble of DNA duplexes containing m1A
In the canonical DNA double helix, Watson–Crick (WC) base pairs (bps) exist in dynamic
equilibrium with sparsely populated (∼ 0.02–0.4%) and short-lived (lifetimes∼ 0.2–2.5 ms) …
equilibrium with sparsely populated (∼ 0.02–0.4%) and short-lived (lifetimes∼ 0.2–2.5 ms) …
RNase P RNA mediated cleavage: substrate recognition and catalysis
LA Kirsebom - Biochimie, 2007 - Elsevier
The universally conserved endoribonuclease P consists of one RNA subunit and,
depending on its origin, a variable number of protein subunits. RNase P is involved in the …
depending on its origin, a variable number of protein subunits. RNase P is involved in the …
Review NMR studies of RNA dynamics and structural plasticity using NMR residual dipolar couplings
M Getz, X Sun, A Casiano‐Negroni… - Biopolymers …, 2007 - Wiley Online Library
An increasing number of RNAs are being discovered that perform their functions by
undergoing large changes in conformation in response to a variety of cellular signals …
undergoing large changes in conformation in response to a variety of cellular signals …
[HTML][HTML] Characterizing complex dynamics in the transactivation response element apical loop and motional correlations with the bulge by NMR, molecular dynamics …
The HIV-1 transactivation response element (TAR) RNA binds a variety of proteins and is a
target for developing anti-HIV therapies. TAR has two primary binding sites: a UCU bulge …
target for developing anti-HIV therapies. TAR has two primary binding sites: a UCU bulge …
Extensive Backbone Dynamics in the GCAA RNA Tetraloop Analyzed Using 13C NMR Spin Relaxation and Specific Isotope Labeling
JE Johnson Jr, CG Hoogstraten - Journal of the American …, 2008 - ACS Publications
Conformational dynamics play a key role in the properties and functions of proteins and
nucleic acids. Heteronuclear NMR spin relaxation is a uniquely powerful site-specific probe …
nucleic acids. Heteronuclear NMR spin relaxation is a uniquely powerful site-specific probe …