The evolution of AMPK and its homologs enabled exquisite responsivity and control of
cellular energetic homeostasis. Recent work has been critical in establishing the …

In eukaryotic cells AMP-activated protein kinase (AMPK) plays a major role in regulating
cellular energy balance. AMPK responds to changes in intracellular adenine nucleotide …

Nonalcoholic fatty liver disease (NAFLD) is a growing worldwide epidemic and an important
risk factor for the development of insulin resistance, type 2 diabetes, nonalcoholic …

The AMP-activated protein kinase (AMPK) is a sensor of cellular energy and nutrient status,
expressed almost universally in eukaryotes as heterotrimeric complexes comprising catalytic …

AMP-activated protein kinase (AMPK) senses energetic stress and, in turn, promotes
catabolic and suppresses anabolic metabolism coordinately to restore energy balance. We …

The AMP‐activated protein kinase (AMPK) is a sensor of cellular energy status that is
expressed in essentially all eukaryotic cells, suggesting that it arose during early eukaryotic …

Type 2 diabetes (T2D) is a metabolic disease characterized by insulin resistance, β-cell
dysfunction, and elevated hepatic glucose output. Over 350 million people worldwide have …

Metformin is the first-line drug treatment for type 2 diabetes. Globally, over 100 million
patients are prescribed this drug annually. Metformin was discovered before the era of target …

AMP-activated protein kinase (AMPK) plays a major role in regulating cellular energy
balance by sensing and responding to increases in AMP/ADP concentration relative to ATP …

In the past decade, studies of the human tumour suppressor LKB1 have uncovered a novel
signalling pathway that links cell metabolism to growth control and cell polarity. LKB1 …