Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …

Transcription factors are involved in a large number of human diseases such as cancers for
which they account for about 20% of all oncogenes identified so far. For long time, with the …

With the introduction of large-scale molecular profiling methods and high-throughput
sequencing technologies, the genomic features of most lymphoid neoplasms have been …

Next-generation sequencing has revealed recurring somatic mutations in Waldenström
macroglobulinemia (WM), including MYD88 (95%-97%), CXCR4 (30%-40%), ARID1A …

Scope The objective of this guideline is to provide healthcare professionals with clear
guidance on the management of patients with Waldenström macroglobulinaemia. In …

Activating MYD88 mutations are present in 95% of Waldenström macroglobulinemia (WM)
patients, and trigger NF-κB through BTK and IRAK. The BTK inhibitor ibrutinib is active in …

The diagnosis of Waldenström's macroglobulinemia (WM), an IgM-associated
lymphoplasmacytic lymphoma, can be challenging due to the different forms of disease …

We analyzed MYD88 and CXCR4 mutation status of 260 patients with Waldenström
macroglobulinemia or IgM monoclonal gammopathy of undetermined significance using …

The phase 3 ASPEN trial (NCT03053440) compared Bruton tyrosine kinase inhibitors
(BTKis), zanubrutinib and ibrutinib, in patients with Waldenström macroglobulinemia (WM) …

Abstract Purpose: Although Bruton tyrosine kinase (BTK) inhibitors have demonstrated
promising efficacy in patients with Waldenström macroglobulinemia (WM), data in Asian …