The mammalian liver tightly regulates its free cysteine pool, and intracellular cysteine in rat
liver is maintained between 20 and 100 nmol/g even when sulfur amino acid intakes are …

Glutathione (GSH) is a tripeptide composed of glutamate, cysteine, and glycine. The first and
rate-limiting step in GSH synthesis is catalyzed by glutamate cysteine ligase (GCL …

The development of strategies to eradicate primary human acute myelogenous leukemia
(AML) cells is a major challenge to the leukemia research field. In particular, primitive …

One of the hallmarks of cancer is the ability to generate and withstand unusual levels of
oxidative stress. In part, this property of tumor cells is conferred by elevation of the cellular …

Continuous control of metabolism and developmental processes is a key feature of live cells.
Cysteine thiol residues of proteins are both exceptionally useful in terms of structural and …

Reactive oxygen species (ROS), mostly derived from mitochondrial activity, can damage
various macromolecules and consequently cause cell death. This ROS activity has been …

Cells in vivo are constantly exposed to reactive oxygen species (ROS) generated
endogenously and exogenously. To defend against the deleterious consequences of ROS …

Glutathione biosynthesis is a key component in the network of plant stress responses that
counteract oxidative damage and maintain intracellular redox environment. Using a …

α-Synuclein aggregates are a common feature of sporadic Parkinson's disease (PD), and
mutations that increase α-synuclein abundance confer rare heritable forms of PD. Although …

In plants, glutathione accumulates in response to different stress stimuli as a protective
mechanism, but only limited biochemical information is available on the plant enzymes that …