The role of serotonin in food intake has been studied for decades. Food intake is mainly
regulated by two brain circuitries:(i) the homeostatic circuitry, which matches energy intake …

The paraventricular nucleus of the hypothalamus (PVH), located in the ventral diencephalon
adjacent to the third ventricle, is a highly conserved brain region present in species from …

Ambiguity regarding the role of glucose-dependent insulinotropic polypeptide (GIP) in
obesity arises from conflicting reports asserting that both GIP receptor (GIPR) agonism and …

The hypothalamic suprachiasmatic (SCN) clock contains several neurochemically defined
cell groups that contribute to the genesis of circadian rhythms. Using cell-specific and …

Activation of melanocortin-4 receptors (MC4Rs) restrains feeding and prevents obesity;
however, the identity, location, and axonal projections of the neurons bearing MC4Rs that …

Abstract 'Sundowning'in dementia and Alzheimer's disease is characterized by early-
evening agitation and aggression. While such periodicity suggests a circadian origin …

Obesity and its associated complications have reached epidemic proportions in the USA
and also worldwide, highlighting the need for new and more effective treatments. Although …

Neurodegenerative diseases (NDDs) are disorders characterized by progressive
deterioration of brain structure and function. Selective neuronal populations are affected …

Chemogenetic technologies enable selective pharmacological control of specific cell
populations. An increasing number of approaches have been developed that modulate …

The suprachiasmatic nucleus (SCN) acts as a master pacemaker driving circadian behavior
and physiology. Although the SCN is small, it is composed of many cell types, making it …