Blood malignancies provide unique opportunities for longitudinal tracking of disease
evolution following therapeutic bottlenecks and for the monitoring of changes in anti-tumor …

The tumor immune microenvironment has been a research hot spot in recent years. The
cytokines and metabolites in the microenvironment can promote the occurrence and …

Autoimmune diseases such as ankylosing spondylitis (AS) can be driven by emerging
neoantigens that disrupt immune tolerance. Here, we developed a workflow to profile …

Regulatory T cells (Treg) are conventionally viewed as suppressors of endogenous and
therapy-induced antitumor immunity; however, their role in modulating responses to immune …

Although DNA mutation drives stem cell aging, how mutation-accumulated stem cells obtain
clonal advantage during aging remains poorly understood. Here, using a mouse model of …

Background Immune checkpoint blockade (ICB) has significantly prolonged survival of non-
small cell lung cancer (NSCLC) patients, although most patients develop mechanisms of …

T cells are present in early stages of the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection and play a major role in disease outcome and long-lasting …

Tools to identify immune dysregulation in patients with unusual autoimmune or inflammatory
conditions remain limited. In this study, we employed mass cytometry immunophenotyping to …

In shrimp, hemocytes play an important role in detoxification and immune defense, and are
where nitrite accumulates during exposure to this toxic environmental pollutant. However …

A balance between pro-inflammatory decidual CD4+ T cells and FOXP3+ regulatory T cells
(FOXP3+ Tregs) is important for maintaining fetomaternal tolerance. Using single-cell RNA …