Current and prospective therapeutic strategies: tackling Candida albicans and Streptococcus mutans cross-kingdom biofilm

Y Li, S Huang, J Du, M Wu, X Huang - Frontiers in Cellular and …, 2023 - frontiersin.org
Candida albicans (C. albicans) is the most frequent strain associated with cross-kingdom
infections in the oral cavity. Clinical evidence shows the co-existence of Streptococcus …

Diversity of GPI-anchored fungal adhesins

LO Essen, MS Vogt, HU Mösch - Biological Chemistry, 2020 - degruyter.com
Selective adhesion of fungal cells to one another and to foreign surfaces is fundamental for
the development of multicellular growth forms and the successful colonization of substrates …

Evolution of loss of heterozygosity patterns in hybrid genomes of Candida yeast pathogens

V Mixão, JC Nunez-Rodriguez, V Del Olmo… - BMC biology, 2023 - Springer
Background Hybrids are chimeric organisms with highly plastic heterozygous genomes that
may confer unique traits enabling the adaptation to new environments. However, most …

Polymorphic centromere locations in the pathogenic yeast Candida parapsilosis

M Ola, CE O'Brien, AY Coughlan, Q Ma… - Genome …, 2020 - genome.cshlp.org
Centromeres pose an evolutionary paradox: strongly conserved in function but rapidly
changing in sequence and structure. However, in the absence of damage, centromere …

Agglutinin-Like Sequence (ALS) Genes in the Candida parapsilosis Species Complex: Blurring the Boundaries Between Gene Families That Encode Cell-Wall …

SH Oh, B Smith, AN Miller, B Staker, C Fields… - Frontiers in …, 2019 - frontiersin.org
The agglutinin-like sequence (Als) proteins are best-characterized in Candida albicans and
known for their role in adhesion of the fungal cell to host and abiotic surfaces. ALS …

Using Genomics to Shape the Definition of the Agglutinin-Like Sequence (ALS) Family in the Saccharomycetales

SH Oh, K Schliep, A Isenhower… - Frontiers in Cellular …, 2021 - frontiersin.org
The Candida albicans agglutinin-like sequence (ALS) family is studied because of its
contribution to cell adhesion, fungal colonization, and polymicrobial biofilm formation. The …

[HTML][HTML] CpALS4770 and CpALS4780 contribution to the virulence of Candida parapsilosis

M Zoppo, M Di Luca, M Franco, C Rizzato… - Microbiological …, 2020 - Elsevier
The ability of yeast to adhere to biotic and abiotic surfaces represents an essential trait
during the early stages of infection. Agglutinin-like sequence (Als) cell-wall proteins play a …

The Emerging Pathogen Candida metapsilosis: Biological Aspects, Virulence Factors, Diagnosis, and Treatment

M Gómez-Gaviria, LC García-Carnero… - Infection and Drug …, 2024 - Taylor & Francis
Fungal infections represent a constant and growing menace to public health. This concern is
due to the emergence of new fungal species and the increase in antifungal drug resistance …

Features of the rare pathogen Meyerozyma guilliermondii strain SO and comprehensive in silico analyses of its adherence-contributing virulence factor agglutinin …

SJ Lim, ND Muhd Noor, S Sabri… - Journal of …, 2023 - Taylor & Francis
Meyerozyma guilliermondii is a rare yeast pathogen contributing to the deadly invasive
candidiasis. M. guilliermondii strain SO, as a promising protein expression host, showed …

B-Cell Epitope Mapping from Eight Antigens of Candida albicans to Design a Novel Diagnostic Kit: An Immunoinformatics Approach

F Vahedi, Y Ghasemi, A Atapour, K Zomorodian… - International Journal of …, 2022 - Springer
Invasive candidiasis is an emerging fungal infection and a leading cause of morbidity in
health care facilities. Despite advances in antifungal therapy, increased antifungal drug …