[HTML][HTML] Multiorgan locked-state model of chronic diseases and systems pharmacology opportunities

CY Ung, C Correia, H Li, CM Adams, JJ Westendorf… - Drug discovery today, 2024 - Elsevier
Highlights•Chronic diseases involve deregulated organ–organ crosstalk.•Interorgan
communication yields multiorgan locked biological states.•Biological locked states stabilize …

Generating bulk RNA-Seq gene expression data based on generative deep learning models and utilizing it for data augmentation

Y Wang, Q Chen, H Shao, R Zhang, H Shen - Computers in Biology and …, 2024 - Elsevier
Large-scale high-throughput transcriptome sequencing data holds significant value in
biomedical research. However, practical challenges such as difficulty in sample acquisition …

Opportunities, challenges and future perspectives of using bioinformatics and artificial intelligence techniques on tropical disease identification using omics data

SM Vidanagamachchi, K Waidyarathna - Frontiers in Digital Health, 2024 - frontiersin.org
Tropical diseases can often be caused by viruses, bacteria, parasites, and fungi. They can
be spread over vectors. Analysis of multiple omics data types can be utilized in providing …

StructmRNA a BERT based model with dual level and conditional masking for mRNA representation

S Nahali, L Safari, A Khanteymoori, J Huang - Scientific Reports, 2024 - nature.com
In this study, we introduce StructmRNA, a new BERT-based model that was designed for the
detailed analysis of mRNA sequences and structures. The success of DNABERT in …

M-GENE: Multiview genes expression network ensemble for bone metabolism-related gene classification

K Yu, W Tan, J Ge, X Li, Y Wang, J Huang, X Chen, S Li… - Neurocomputing, 2025 - Elsevier
In this paper, a novel multi-view gene expression network ensemble (M-GENE) pipeline has
been proposed to predict correlations between genes and phenotypes using bulk RNA-seq …

ARGai 1.0: A GAN Augmented in Silico Approach for Identifying Resistant Genes and Strains in E. coli using Vision Transformer

DSK Nayak, R Das, SK Sahoo, T Swarnkar - Computational Biology and …, 2025 - Elsevier
The emergence of infectious disease and antibiotic resistance in bacteria like Escherichia
coli (E. coli) shows the necessity for novel computational techniques for identifying essential …

Single‑cell RNA sequencing data dimensionality reduction

VL Zogopoulos, I Tsotra… - World Academy of …, 2025 - spandidos-publications.com
Single‑cell RNA sequencing (scRNA‑Seq) provides detailed insight into gene expression at
the individual cell level, revealing hidden cell diversity. However, scRNA‑Seq data pose …

DRGAT: Predicting Drug Responses Via Diffusion-Based Graph Attention Network

E Sefer - Journal of Computational Biology, 2024 - liebertpub.com
Accurately predicting drug response depending on a patient's genomic profile is critical for
advancing personalized medicine. Deep learning approaches rise and especially the rise of …

Diffusion-based artificial genomes and their usefulness for local ancestry inference

A Szatkownik, L Planche, M Demeulle, T Chambe… - bioRxiv, 2024 - biorxiv.org
The creation of synthetic data through generative modeling has emerged as a significant
area of research in genomics, offering versatile applications from tailoring functional …

TB-SMGAN: A GAN Based Hybrid Data Augmentation Framework on Chest X-ray Images and Reports

HB Özfidan, MU Şimşek - Gazi University Journal of Science Part A …, 2024 - dergipark.org.tr
Data augmentation is a common practice in image classification, employing methods such
as reflection, random cropping, re-scaling, and transformations to enhance training data …