G-protein-coupled bile acid receptor, Gpbar1 (TGR5), is a member of G-protein-coupled
receptor (GPCR) superfamily. High levels of TGR5 mRNA were detected in several tissues …

In the past decade substantial progress has been made in understanding how the
insurgence of chronic low-grade inflammation influences the physiology of several …

GPBAR1 (also known as TGR5) is a G-protein-coupled receptor (GPCR) that triggers
intracellular signals upon ligation by various bile acids. The receptor has been studied …

Bile acids are steroid-derived molecules synthesized in the liver, secreted from hepatocytes
into the bile canaliculi, and subsequently stored in the gall bladder. During the feeding, bile …

Background and purpose TGR5 plays an important role in many physiological processes.
However, the functions of TGR5 in the regulation of the glucose metabolism and insulin …

TGR5, a G-protein coupled receptor, acts as a promising target for the treatment of diabetes,
obesity and metabolic syndromes. Understanding the activation of TGR5, the structural …

Takeda G-protein-coupled receptor 5 (TGR5) is emerging as an important and promising
target for the development of anti-diabetic drugs. To understand the structural characteristics …

The G protein-coupled bile acid receptor 1 (GPBAR1) or TGR5 is widely distributed across
organs, including the small intestine, stomach, liver, spleen, and gallbladder. Many studies …

The G protein-coupled receptor TGR5 is a membrane receptor for bile acids. Its agonism
increases energy expenditure and controls blood glucose through secretion of glucagon-like …

Farnesoid X receptor and Takeda G-protein-coupled receptor-5 are well known bile acid
receptors and act as promising targets for the drug development and treatment of diabetes …